Randomized trial of amino acid mixture combined with physical activity promotion for abdominal fat reduction in overweight adults.
Randomized trial of amino acid mixture combined with physical activity promotion for abdominal fat reduction in overweight adults.
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DOI：
10.2147/dmso.s153151
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Nakata Y
中科院分区：
文献类型：
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作者：
Ueda K;Sasai H;Tsujimoto T;Sanbongi C;Ikegami S;Kobayashi H;Shioya N;Suzuki S;Nakata Y
这项研究的目的是测试每天摄入1,500 mg精氨酸、丙氨酸和苯丙氨酸混合物(A-Mix)与促进体力活动相结合对超重成年人腹部脂肪减少的效果。2016年12月至2017年5月，在日本东京南区的一个中心进行了为期12周的安慰剂对照、双盲、平行组、随机试验，并进行了4周的随访期。对2017年6月至8月期间的数据进行了分析。研究参与者是20-年龄范围内的200名超重成年人。参与者被随机分配到A-Mix组(n=100)或安慰剂组(n=100)，分别服用500毫升含1,500 mg或0 mg A-Mix的测试饮料，为期12周。所有参与者在0周至12周期间通过每月的体育活动保持体育锻炼的生活方式。主要结果是通过计算机断层扫描评估的腹部总脂肪、皮下脂肪和内脏脂肪区域在12周内的变化。在200名登记的参与者中，199人(99%)完成了为期12周的干预和4周的随访期。对194名参与者的按方案分析表明，与安慰剂组相比，A-Mix组的腹部总脂肪面积显著减少(差异，10.0cm2；95%可信区间：0.4cm2-19.6cm2；P=0.041)。腹部皮下脂肪面积也有类似的结果(差值，7.4cm2；95%可信区间：0.1cm2-14.7cm2；P=0.047)。没有发生与研究相关的不利事件。A-Mix补充剂与促进体力活动相结合，促进了超重成年人腹部脂肪的减少。
The purpose of this study was to test the efficacy of arginine, alanine, and phenylalanine mixture (A-mix) ingestion at 1,500 mg/day in combination with the promotion of physical activity for abdominal fat reduction in overweight adults. A placebo-controlled, double-blind, parallel-group, randomized trial for 12 weeks combined with a 4-week follow-up period was conducted at a single center in Minato-ku, Tokyo, Japan, between December 2016 and May 2017. Data were analyzed between June and August 2017. The study participants were 200 overweight adults within the age range of 20–64 years. The participants were randomly assigned to the A-mix group (n=100) or a placebo group (n=100) and were administered 500 mL of test beverage containing 1,500 or 0 mg of A-mix, respectively, for 12 weeks. All participants maintained a physically active lifestyle between week 0 and week 12 through monthly sessions of physical activity. The primary outcomes were the 12-week changes in the abdominal total, subcutaneous, and visceral fat areas, as assessed by computed tomography. Of the 200 enrolled participants, 199 (99%) accomplished the 12-week intervention and 4-week follow-up period. The per-protocol-based analysis for 194 participants demonstrated that the abdominal total fat area decreased significantly in the A-mix group compared with that in the placebo group (difference, 10.0 cm2; 95% confidence interval [CI]: 0.4–19.6 cm2; P=0.041). Comparable outcomes were obtained for the abdominal subcutaneous fat area (difference, 7.4 cm2; 95% CI: 0.1–14.7 cm2; P=0.047). No study-related unfavorable events occurred. A-mix supplementation in combination with physical activity promotion facilitated abdominal fat reduction in overweight adults.