Marker-based ballistocardiographic artifact correction improves spike identification in EEG-fMRI of focal epilepsy patients
Marker-based ballistocardiographic artifact correction improves spike identification in EEG-fMRI of focal epilepsy patients
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DOI：
10.1016/j.clinph.2016.05.361
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发表时间：
2016-08-01
影响因子：
4.7
通讯作者：
LeVan, Pierre
中科院分区：
文献类型：
--
作者：
Koerbl, Katharina;Jacobs, Julia;LeVan, Pierre
目的：心冲击描记 (BCG) 伪影类似于发作间期癫痫放电 (IED)，可能导致 EEG-fMRI 中 IED 识别不正确。本研究调查了使用莫尔相位跟踪 (MPT) 标记信息校正的 EEG 中标记的 IED。方法：使用常规方法对 18 名患者的 EEG-fMRI 进行处理以去除 BCG，而 9 名患者使用 MPT 标记。首先在没有心电图信息的情况下标记简易爆炸装置。在第二次审查中，与 BCG 同步的可疑简易爆炸装置被丢弃。每次审查后，对标记的简易爆炸装置进行事件相关的功能磁共振成像分析。结果：2个患者组中可疑简易爆炸装置的比例没有发现差异。然而，在没有 MPT 标记记录的 18 名患者中，有 11 名患者的 IED 时间分布与心动周期显着相关，但在 9 名有标记患者中，只有 2 名患者的 IED 时间分布与心动周期显着相关。在没有标记记录的患者中，未能丢弃可疑的 IED 会导致 fMRI 地图更加不准确和激活距离更远。结论：基于 MPT 记录的 BCG 伪影校正可以更直接地识别大多数患者中不需要 ECG 信息的 IED。意义：基于标记的心冲击描计伪影校正极大地促进了 EEG-fMRI 对发作间期放电发生器的研究。 (C) 2016 年国际临床神经生理学联合会。由爱思唯尔爱尔兰有限公司出版。保留所有权利。
Objectives: Ballistocardiographic (BCG) artifacts resemble interictal epileptic discharges (IEDs) and can lead to incorrect IED identification in EEG-fMRI. This study investigates IEDs marked in EEGs corrected using information from a moire phase tracking (MPT) marker.Methods: EEG-fMRI from 18 patients was processed with conventional methods for BCG removal, while 9 patients used a MPT marker. IEDs were marked first without ECG information. In a second review, suspicious IEDs synchronous with the BCG were discarded. After each review, an event-related fMRI analysis was performed on the marked IEDs.Results: No difference was found in the proportion of suspicious IEDs in the 2 patient groups. However, the distribution of IED timings was significantly related to the cardiac cycle in 11 of 18 patients recorded without MPT marker, but only 2 of 9 patients with marker. In patients recorded without marker, failing to discard suspicious IEDs led to more inaccurate fMRI maps and more distant activations.Conclusions: BCG artifact correction based on MPT recordings allowed a more straightforward identification of IEDs that did not require ECG information in the large majority of patients.Significance: Marker-based ballistocardiographic artifact correction greatly facilitates the study of the generators of interictal discharges with EEG-fMRI. (C) 2016 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.