Mortality experience of workers exposed to vinyl chloride monomer in the manufacture of polyvinyl chloride in Great Britain.
Mortality experience of workers exposed to vinyl chloride monomer in the manufacture of polyvinyl chloride in Great Britain.
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DOI：
10.1136/oem.34.1.1
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发表时间：
1977-02
期刊：
影响因子：
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通讯作者：
A. J. Fox;P. Collier;W. Crosbie;M. B. Clarke;R. Cox;N. McIver;I. Anderson;H. Evans;G. C. Liddle;J. L. Cowan;H. Guirgis;J. Sanderson;W. Taylor;J. Thompson;A. Holmes;J. Booth;F. D.C.;Muir;Z. Skurić
中科院分区：
文献类型：
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作者：
A. J. Fox;P. Collier;W. Crosbie;M. B. Clarke;R. Cox;N. McIver;I. Anderson;H. Evans;G. C. Liddle;J. L. Cowan;H. Guirgis;J. Sanderson;W. Taylor;J. Thompson;A. Holmes;J. Booth;F. D.C.;Muir;Z. Skurić
在1940年至1974年期间，有7000多名男子曾在聚氯乙烯生产过程中接触过氯乙烯单体。其中大约99%的人被追踪并研究了他们的死亡经历。总体标准化死亡率为75比4，与全国死亡率相比有显著下降。发现肝癌4例。其中2例经肝脏病理学家证实为血管肉瘤，2例非血管肉瘤。没有证据支持这种假设，即肝癌以外的癌症与暴露于氯乙烯单体有关。这两例血管肉瘤病例都是在暴露于高浓度单体的男性中发现的，尽管第二例患者在首次暴露后仅8年就死亡了。自第二次世界大战以来，英国的钢铁业发展迅速，过去十年有超过50%的男性进入钢铁业。因此，关于氯乙烯单体对该行业男性死亡率影响的结论必须加以修正，因为其全部影响可能尚未得到证实。
Identification particulars were obtained for over 7000 men who were at some time between 1940 and 1974 exposed to vinyl chloride monomer in the manufacture of polyvinyl chloride. Approximately 99% of these men have been traced and their mortality experience studied. The overall standardised mortality ratio, 75-4, shows a significant reduction compared with the national rates. Four cases of liver cancer were found. Two of these have been confirmed by a panel of liver pathologists as angiosarcoma and two as not angiosarcoma. There is no evidence to support the hypothesis that cancers other than those of the liver are associated with exposure to vinyl chloride monomer. The two cases of angiosarcoma were found in men who had been exposed to high concentrations of the monomer although the second man died only eight years after first exposure. The industry in Great Britain has expanded considerably since the second world war with over 50% of men having entered with the last decade. Conclusions drawn about the effect of vinyl chloride monomer on the mortality experience of men in this industry must consequently be tempered by the reservation that the full impact may not yet be in evidence.