The hyperbolic strength-duration relationship of defibrillation threshold
The hyperbolic strength-duration relationship of defibrillation threshold
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DOI：
10.1109/tbme.2008.921147
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发表时间：
2008-08-01
影响因子：
4.6
通讯作者：
Irnich, Wemer
中科院分区：
文献类型：
--
作者：
Irnich, Wemer
方波脉冲除颤已被证明具有双曲线强度-持续时间关系。这样的双曲线关系是否也存在于今天普遍使用的指数衰减脉冲中？本文假设指数衰减脉冲服从双曲线强度-持续时间关系，计算结果，并建议如何研究这样的阈值。如果电流存在强度-持续时间关系，则相应的电荷阈值必须是韦斯直线阈值。类似地，对于指数衰减脉冲，幅度对脉冲持续时间（PD）的积分必须作为PD的函数来计算。如果该函数是线性相关的，则平均电压具有双曲线强度-持续时间关系，而峰值电压不具有双曲线强度-持续时间关系。峰值幅度曲线具有最小值向右移动，随着时间常数RC的增加，限制了有用PD的允许范围。为了证明指数衰减脉冲具有双曲线关系，测试必须分六个步骤进行，这些步骤已在文献中发表。平均电压确实具有双曲线强度-持续时间关系。只要峰值电压阈值相关且PD大于允许值，则无法正确计算时值。
Defibrillation with square-wave pulses has proved to possess hyperbolic strength-duration relationship. Does such a hyperbolic relation also exist for exponentially decaying pulses as they are commonly used today? This paper hypothesizes that exponentially decaying pulses obey hyperbolic strength-duration relationship, calculates the consequences, and advises of how such thresholds should be investigated. If the strength-duration relationship exists for current, the corresponding charge threshold must be a Weiss' straight threshold line. In analogy, for exponentially decaying pulses, the integral of the amplitude over pulse duration (PD) must be calculated as a function of PD., If this function is linearly correlated, the mean voltage possesses a hyperbolic strength-duration relationship, whereas the peak voltage does not. Peak amplitude curves possess minima shifting to the right with increasing time constant RC limiting the allowed range of useful PDs. To prove that exponentially decaying pulses have a hyperbolic relationship, testing must be done in six steps that are demonstrated with results published in literature. Mean voltages have, indeed, hyperbolic strength-duration relationship. Chronaxie is not calculated correctly as long as peak voltage thresholds are correlated and PDs are greater than allowed.