PERIPHERAL CONTROL OF THE CAT STEP CYCLE .1. PHASE DEPENDENT EFFECTS OF RAMP-MOVEMENTS OF THE HIP DURING FICTIVE LOCOMOTION
PERIPHERAL CONTROL OF THE CAT STEP CYCLE .1. PHASE DEPENDENT EFFECTS OF RAMP-MOVEMENTS OF THE HIP DURING FICTIVE LOCOMOTION
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DOI：
10.1111/j.1748-1716.1981.tb06867.x
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发表时间：
1981-01-01
期刊：
影响因子：
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通讯作者：
GRILLNER, S
中科院分区：
文献类型：
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作者：
ANDERSSON, O;GRILLNER, S
急性脊髓和curarized猫可以产生虚构的自发活动后，静脉注射Nialamid [单胺氧化酶抑制剂]，然后4-氨基吡啶和L-多巴。在周围神经纤维中可以记录到屈肌和伸肌的传出爆发活动。斜坡形成的运动施加在髋关节在恒定的角速度在不同阶段的自发传出爆发活动。周期持续时间明显受到影响。在步进循环的早期部分（在屈肌活动期间）应用的屈曲或伸展斜坡将延长循环持续时间，但在循环的后期部分，将发生显著的缩短效应。从延长到缩短的过渡对于延长斜坡来说是非常陡峭的，随后从缩短到延长的周期逐渐增加。这种类型的相位响应曲线表达了对中枢模式发生器的有效的外周调节作用。在屈肌爆发开始时应用的斜坡运动（屈曲或伸展）将加强屈肌活动。相反，在屈肌爆发结束时，存在具有正反馈的方向灵敏度，导致屈肌活动对于屈曲斜坡的激励，但是屈肌活动对于伸展斜坡的抑制。伸展斜坡还显示出位置依赖性效应，其增强了屈肌对更多伸展髋位置的响应。
Acute spinal and curarized cats can generate fictive locomotor activity after an i.v. injection of Nialamid [a monoamine oxidase inhibitor] followed by 4-aminopyridine and L-dopa. The efferent burst activity to flexors and extensors can be recorded in peripheral nerve filaments. Ramp-formed movements were applied in the hip at constant angular velocity in different phases of the spontaneous efferent burst activity. The cycle duration was markedly influenced. A flexion or an extension ramp applied in the early part of the step-cycle (during flexor activity) will prolong the cycle duration, but in the later part of the cycle instead a marked shortening effect will occur. The transition from a prolongation to a shortening is very steep for the extension-ramps, with a subsequent gradual increase from a shortening to a lengthening of the cycle. This type of phase response curve expresses a potent peripheral modulatory effect on the central pattern generator. A ramp movement (flexion or extension) applied in the beginning of the flexor burst will reinforce the flexor activity. In the end of the flexor burst instead there is a directional sensitivity with positive feedback, resulting in an excitation of the flexor activity for flexion ramps, but a depression of the flexor activity for extension-ramps. Extension-ramps also show a position dependent effect which enhances the response in the flexors for more extended hip positions.