Laterality of motor symptom onset and facial expressivity in Parkinson disease using face digitization.
Laterality of motor symptom onset and facial expressivity in Parkinson disease using face digitization.
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DOI：
10.1080/1357650x.2021.1946077
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发表时间：
2022-01
期刊：
影响因子：
1.4
通讯作者：
Bowers D
中科院分区：
文献类型：
--
作者：
Ratajska AM;Nisenzon AN;Lopez FV;Clark AL;Gokcay D;Okun MS;Bowers D
帕金森病(PD)的运动症状起病通常是单侧的。以前的工作表明，运动症状的偏侧性也可能影响非运动症状，包括认知和情绪感知。根据情绪加工的大脑半球差异，我们测试了与右侧/左脑运动发作相比，左侧/右脑运动发作是否与面部影响的表达更差相关。我们评估了30例特发性帕金森病患者(15例左侧运动性发作，15例右侧运动性发作)和20名健康对照的面部运动变化与面部影响的关系。参与者在摆出三种面部表情时被拍摄下来：恐惧、愤怒和快乐。表情被数字化，并使用软件进行分析，该软件提取了三个变量：两个衡量动态运动变化的指标(总熵和熵百分比变化)和一个启动面部表情的时间指标(潜伏期)。两组在总运动量变化或百分比变化方面没有差异。然而，左侧帕金森病患者在发起愤怒和快乐的面部表情方面明显慢于右侧帕金森病患者和对照组。我们的结果表明，出现左侧症状的帕金森病患者在启动三种面部表情中的两种时有更长的潜伏期，这可能反映了有意行为的侧向效应。
The onset of motor symptoms in Parkinson disease (PD) is typically unilateral. Previous work has suggested that laterality of motor symptoms may also influence non-motor symptoms including cognition and emotion perception. In line with hemispheric differences in emotion processing, we tested whether left side/right brain motor onset was associated with worse expression of facial affect when compared to right side/left brain motor onset. We evaluated movement changes associated with facial affect in 30 patients with idiopathic PD (15 left-sided motor onset, 15 right-sided motor onset) and 20 healthy controls. Participants were videotaped while posing three facial expressions: fear, anger, and happiness. Expressions were digitized and analyzed using software that extracted three variables: two measures of dynamic movement change (total entropy and entropy percent change) and a measure of time to initiate facial expression (latency). The groups did not differ in overall amount of movement change or percent change. However, left-sided onset PD patients were significantly slower in initiating anger and happiness facial expressions than were right-sided onset PD patients and controls. Our results indicated PD patients with left-sided symptom onset had greater latency in initiating two of three facial expressions, which may reflect laterality effects in intentional behavior.