Behavioral Approach System and Behavioral Inhibition System sensitivities and bipolar spectrum disorders: prospective prediction of bipolar mood episodes
Behavioral Approach System and Behavioral Inhibition System sensitivities and bipolar spectrum disorders: prospective prediction of bipolar mood episodes
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DOI：
10.1111/j.1399-5618.2007.00547.x
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发表时间：
2008-03-01
影响因子：
5.4
通讯作者：
Hogan, Michael E.
中科院分区：
文献类型：
--
作者：
Alloy, Lauren B.;Abramson, Lyn Y.;Hogan, Michael E.
研究发现，双相情感障碍与行为途径系统（BAS）超敏感性相关，单极和双相情感障碍与行为抑制系统（BIS）高敏感性相关，但缺乏对这些关系的前瞻性研究。我们测试了BAS和BIS敏感性是否能预测双相情感障碍个体重性抑郁、轻躁狂和躁狂发作的新发作时间。方法：我们对136例双相II型或循环胸腺患者和157例人口统计学匹配的正常对照进行了平均33个月的前瞻性随访。参与者在第1时间完成BIS/BAS量表和症状测量，每4个月随访一次半结构化诊断访谈。结果：双相情感障碍组在控制了时间1期症状后，其时间1期BAS评分高于正常对照组，但BIS评分不高于正常对照组。在双相情感障碍参与者中，高BAS敏感性预测到轻躁狂和躁狂发作的时间较短，而高BIS敏感性预测到重度抑郁发作的生存时间较短，控制了初始症状。结论：与双相情感障碍的BAS超敏模型一致，高反应性BAS易发生（轻度）躁狂发作。此外，高度敏感的BIS会增加重度抑郁发作的风险。
Objectives: Research has found that bipolar spectrum disorders are associated with Behavioral Approach System (BAS) hypersensitivity and both unipolar and bipolar depression are associated with high Behavioral Inhibition System (BIS) sensitivity, but prospective studies of these relationships are lacking. We tested whether BAS and BIS sensitivities prospectively predicted the time to new onsets of major depressive and hypomanic and manic episodes in bipolar spectrum individuals.Methods: We followed 136 bipolar II or cyclothymic and 157 demographically matched normal control individuals prospectively for an average of 33 months. Participants completed the BIS/BAS scales and symptom measures at Time 1 and semi-structured diagnostic interviews every four months of follow-up.Results: The bipolar spectrum group exhibited higher Time 1 BAS, but not BIS, scores than the normal controls, controlling for Time 1 symptoms. Among bipolar spectrum participants, high BAS sensitivity prospectively predicted a shorter time to onset of hypomanic and manic episodes, whereas high BIS sensitivity predicted less survival time to major depressive episodes, controlling for initial symptoms.Conclusions: Consistent with the BAS hypersensitivity model of bipolar disorder, a highly responsive BAS provides vulnerability to onsets of (hypo)manic episodes. In addition, a highly sensitive BIS increases risk for major depressive episodes.