The neurophysiology and effect of deep brain stimulation in a patient with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism.
The neurophysiology and effect of deep brain stimulation in a patient with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism.
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DOI：
10.3171/2008.8.jns08882
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发表时间：
2009-02
影响因子：
4.1
通讯作者：
Starr PA
中科院分区：
文献类型：
--
作者：
Christine CW;Langston JW;Turner RS;Starr PA
Parkinsonism caused by MPTP exposure was first identified in intravenous drug users. The neurotoxicant has since been used extensively in nonhuman primates to induce an experimental model of Parkinson’s disease. We examined the intraoperative physiology and the efficacy of subthalamic nucleus deep brain stimulation (DBS) in 1 of only 4 known living humans with MPTP-induced parkinsonism. The physiologic recordings were consistent with recordings from MPTP-treated primates and humans with Parkinson’s disease, thus further validating the MPTP model for the study of the neurophysiology of the nigrostriatal dopaminergic deficit in Parkinson’s disease. Furthermore, DBS offered significant clinical improvement in this patient similar to that seen in idiopathic Parkinson’s disease. This unique case has important implications for translational research that employs the MPTP-primate model for symptomatic therapy in Parkinson’s disease.
