Environmental risk factors and Parkinson's disease: A metaanalysis
Environmental risk factors and Parkinson's disease: A metaanalysis
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DOI：
10.1006/enrs.2001.4264
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发表时间：
2001-06-01
影响因子：
8.3
通讯作者：
Priyadarshi, SS
中科院分区：
文献类型：
--
作者：
Priyadarshi, A;Khuder, SA;Priyadarshi, SS
该研究的目的是研究帕金森病（PD）与环境因素（如生活在农村地区、井水使用、农业、接触农场动物或生活在农场）和杀虫剂之间的关系。对同行评议研究进行了一系列荟萃分析，其中16项研究涉及农村地区生活，18项研究涉及井水饮用，11项研究涉及农业，14项研究涉及农药。在荟萃分析之前，对所有研究进行回顾和评估异质性和发表偏倚。研究间存在显著异质性，采用随机和固定效应模型计算联合优势比（OR）。大多数研究报告，暴露于农村生活和农业等环境因素中，PD的风险一致升高。所有研究中农村居民的综合OR为1.56[95%可信区间（95% CI） 1.18-2.07]，在美国进行的研究的OR为2.17（95% CI 1.54-3.06）。所有研究中井水使用的综合OR为1.26 (95% CI 0.97-1.64)，美国研究的OR为1.44（95% CI 0.92-2.24）。在所有研究中，农业、接触农场动物或生活在农场的综合OR为1.42 (95% CI 1.05-1.91)，在美国进行的研究中为1.72（95% CI 1.20-2.46）。所有研究中农药暴露的综合OR为1.85(95% CI 1.31-2.60)，美国研究的OR为2.16（95% CI 1.95-2.39）。由于所报告数据的不精确性，无法建立剂量-反应关系。我们的研究结果表明，生活在农村地区，饮用井水，耕作和接触杀虫剂可能是患帕金森病的危险因素。(C) 2001学术出版社。
The study aim was to examine the association between Parkinson's disease (PD) and exposure to environmental factors such as living in a rural area, well water use, farming, exposure to farm animals, or living on a farm, and pesticides. A series of metaanalyses of peer-reviewed studies were performed, using 16 studies for living in rural area, 18 studies for well water drinking, 11 studies for farming, and 14 studies for pesticides. Prior to the metaanalyses, all studies were reviewed and evaluated for heterogeneity and publication bias. Significant heterogeneity among studies was detected and combined odds ratio (OR) was calculated using the random and the fixed-effect models. The majority of the studies reported consistent elevation in the risk of PD with exposure to environmental factors such as rural living and farming. The combined OR for rural residence was 1.56 [95% confidence interval (95% CI) 1.18-2.07] for all the studies, and 2.17(95% CI 1.54-3.06) for studies performed in United States. The combined OR for well water use was 1.26 (95% CI 0.97-1.64) for all the studies, and 1.44(95% CI 0.92-2.24) for studies done in United States. The combined OR for farming, exposure to farm animals, or living on a farm was 1.42 (95% CI 1.05-1.91) for all studies, and 1.72(95% CI 1.20-2.46) for studies done in United States. The combined OR for pesticides exposure was 1.85(95% CI 1.31-2.60) for all studies, and 2.16(95% CI 1.95-2.39) for studies done in United States. Dose-response relationships could not be established due to the imprecise nature of the reported data. Our findings suggest that living in a rural area, drinking well water, farming, and exposure to pesticides may be a risk factor for developing PD. (C) 2001 Academic Press.