The production of “bacteria-free” mice. Relationship between fecal flora and bacterial population of the skin
The production of “bacteria-free” mice. Relationship between fecal flora and bacterial population of the skin
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“无菌”小鼠的产生。粪便菌群与皮肤细菌群之间的关系。
DOI：
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发表时间：
2005
期刊：
影响因子：
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通讯作者：
C. A. Sturm
中科院分区：
文献类型：
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作者：
D. Waaij;C. A. Sturm
在小鼠中，经过几天口服吸收极少的抗生素治疗后，粪便中的细菌菌群被消除。在这种治疗过程中，皮肤的细菌数量急剧减少。 9 周后，背部皮肤培养呈阴性。经过 12 周的治疗后，约 50% 的小鼠体内始终没有可通过常规培养方法检测到的微生物。治疗第四天对皮肤进行消毒（氯己定）对这些动物获得阴性“全身培养物”所需的时间没有影响。
In mice, after a few days of oral treatment with antibiotics which are minimally absorbed, the bacterial fecal flora is eliminated. In the course of such treatment, the bacterial population of the skin becomes drastically reduced. After 9 weeks, cultures from the skin of the back are negative. Following 12 weeks of treatment, about 50% of the mice are shown to be persistently free of microbes that are detectable by conventional methods of culturing.Disinfection of the skin (chlorhexidine) on the fourth day of treatment had no effect on the time required to obtain negative “whole-body cultures” in these animals.