The Emerging Role of microRNAs in Aquaporin Regulation.
The Emerging Role of microRNAs in Aquaporin Regulation.
复制标题
DOI：
10.3389/fchem.2018.00238
复制
发表时间：
2018
影响因子：
5.5
通讯作者：
Soveral G
中科院分区：
文献类型：
--
作者：
Gomes A;da Silva IV;Rodrigues CMP;Castro RE;Soveral G
水通道蛋白（AQPs）是广泛分布于人体组织中的膜通道。aqp对水和能量稳态至关重要，参与了广泛的病理生理过程，如水肿、脑损伤、青光眼、肾源性尿崩症、唾液腺和泪腺功能障碍、癌症、肥胖和相关代谢并发症。令人信服的证据表明，aqp是具有潜在广泛应用的治疗干预靶点。然而，由于缺乏选择性和稳定性，或者相关的毒性阻碍了体内研究，很难找到有效的AQP调节剂。MicroRNAs （miRNAs）是一种天然存在的非编码小rna，可调节转录后基因表达，并与多种疾病有关。最近发现的mirna是AQP表达的内源性调节剂，为靶向这些蛋白提供了另一种方法，并为治疗应用开辟了新的前景。这篇综述汇总了目前关于miRNA与aqp相互作用的知识，强调了miRNA在aqp基础疾病调节中的潜力。
Aquaporins (AQPs) are membrane channels widely distributed in human tissues. AQPs are essential for water and energy homeostasis being involved in a broad range of pathophysiological processes such as edema, brain injury, glaucoma, nephrogenic diabetes insipidus, salivary and lacrimal gland dysfunction, cancer, obesity and related metabolic complications. Compelling evidence indicates that AQPs are targets for therapeutic intervention with potential broad application. Nevertheless, efficient AQP modulators have been difficult to find due to either lack of selectivity and stability, or associated toxicity that hamper in vivo studies. MicroRNAs (miRNAs) are naturally occurring small non-coding RNAs that regulate post-transcriptional gene expression and are involved in several diseases. Recent identification of miRNAs as endogenous modulators of AQP expression provides an alternative approach to target these proteins and opens new perspectives for therapeutic applications. This mini-review compiles the current knowledge of miRNA interaction with AQPs highlighting miRNA potential for regulation of AQP-based disorders.