Biocompatible Wax-Based Microcapsules with Hermetic Sealing for Thermally Triggered Release of Actives
Biocompatible Wax-Based Microcapsules with Hermetic Sealing for Thermally Triggered Release of Actives
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DOI：
10.1021/acsami.1c04652
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发表时间：
2021-07-13
影响因子：
9.5
通讯作者：
Lee, Hyomin
中科院分区：
文献类型：
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作者：
Ryu, Sang A.;Hwang, Yoon-Ho;Lee, Hyomin
我们提出了一种微流体方法，该方法利用温度响应性和生物相容性棕榈油作为微胶囊中的壳材料，以同时实现气密密封以及按需温度触发释放封装的活性物质。与普通石蜡不同（e。例如，在一个实施例中，二十烷），包含棕榈油的微胶囊壳在冷冻过程中不形成孔或裂缝，并提供气密密封，一种几乎完美的密封，其在延长的时间段内将含有活性物质的芯与周围环境分离。这允许有效地隔离和保护复杂货物，例如具有高扩散性的小分子、强酸和包括烟酰胺的化妆品活性物质。此外，棕榈油壳在高于限定的熔融温度下熔融，允许按需释放包封的活性物质。此外，棕榈油具有生物相容性，可食用，并且在用于个人护理和化妆品时留下最小的足迹，为化妆品应用的微胶囊设计提供了新的视角。
We present a microfluidic approach that utilizes temperature-responsive and biocompatible palm oil as the shell material in microcapsules to simultaneously achieve hermetic sealing as well as on-demand temperature-triggered release of the encapsulated actives. Unlike common paraffin waxes (e. g., eicosane), microcapsule shells comprising palm oil do not form pores or cracks during freezing and provide a hermetic seal, a nearly perfect seal that separates the core containing the actives from the surrounding environment over a prolonged period of time. This allows effective isolation and protection of complex cargoes such as small molecules with high diffusivity, strong acids, and cosmetic actives including niacinamide. Moreover, the palm oil shell melts above the defined melting temperature, allowing the ondemand release of the encapsulated actives. Furthermore, palm oil is biocompatible, is edible, and leaves a minimal footprint when used in personal care and cosmetic products, offering new perspectives in the design of microcapsules for cosmetic applications.