Positron emission tomography metabolic correlates of apathy in Alzheimer disease
Positron emission tomography metabolic correlates of apathy in Alzheimer disease
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DOI：
10.1001/archneur.64.7.1015
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发表时间：
2007-07-01
影响因子：
--
通讯作者：
Sultzer, David L.
中科院分区：
文献类型：
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作者：
Marshall, Gad A.;Monserratt, Lorena;Sultzer, David L.
背景：冷漠是阿尔茨海默病（AD）最常见的神经精神症状。临床、单光子发射计算机断层扫描、磁共振成像和病理学研究表明，AD患者的情感淡漠与额叶功能障碍有关，最支持前扣带回异常，但没有明确的定位。目的：研究AD患者情感淡漠与正电子发射断层扫描的皮质代谢率之间的关系。设计：41例可能患有AD的受试者接受了[ F-18]氟脱氧葡萄糖正电子发射断层扫描成像以及神经精神和认知评估。阿尔茨海默病阴性症状评估量表的总体子量表评分用于指定是否存在有临床意义的冷漠。全脑体素为基础的分析进行了统计参数映射（SPM 2，惠康部的成像神经科学，伦敦，英格兰），这产生了显着的地图比较2 groups.Results：27（66%）的主题没有冷漠，而14（34%）有冷漠。统计参数图分析显示，双侧前扣带回区向内侧眶额区延伸的活动显著减少（P
Background: Apathy is the most common neuropsychiatric manifestation in Alzheimer disease ( AD). Clinical, single-photon emission computed tomography, magnetic resonance imaging, and pathologic studies of apathy in AD have suggested an association with frontal dysfunction, most supportive of anterior cingulate abnormalities, but without a definitive localization.Objective: To examine the association between apathy and cortical metabolic rate on positron emission tomography in AD.Design: Forty-one subjects with probable AD underwent [ F-18] fluorodeoxyglucose positron emission tomography imaging and neuropsychiatric and cognitive assessments. Global subscale scores from the Scale for the Assessment of Negative Symptoms in Alzheimer Disease were used to designate the absence or presence of clinically meaningful apathy. Whole-brain voxel-based analyses were performed using statistical parametric mapping ( SPM2; Wellcome Department of Imaging Neuroscience, London, England), which yielded significance maps comparing the 2 groups.Results: Twenty-seven ( 66%) subjects did not have apathy, whereas 14 ( 34%) had apathy. Statistical parametric mapping analysis revealed significant reduced activity in the bilateral anterior cingulate region extending inferiorly to the medial orbitofrontal region ( P