Blood-brain barrier link to human cognitive impairment and Alzheimer's Disease.
Blood-brain barrier link to human cognitive impairment and Alzheimer's Disease.
复制标题
血脑屏障与人类认知障碍和阿尔茨海默氏病的联系。
DOI：
10.1038/s44161-021-00014-4
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发表时间：
2022-03
期刊：
影响因子：
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通讯作者：
Zlokovic, Berislav V
中科院分区：
文献类型：
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作者：
Barisano, Giuseppe;Montagne, Axel;Kisler, Kassandra;Schneider, Julie A;Wardlaw, Joanna M;Zlokovic, Berislav V
血管功能障碍常见于与认知障碍、痴呆和阿尔茨海默病（AD）相关的疾病。神经影像学和液体生物标志物的最新进展表明，血管功能障碍不是单纯伴随神经元功能障碍的旁观者。脑血管完整性丧失，通常被称为血脑屏障（BBB）的破坏，最近被证明是人类认知功能障碍的早期生物标志物，可能是与年龄相关的认知衰退的潜在机制。血脑屏障损伤可引发或进一步引发一系列组织损伤，导致突触和神经元功能障碍以及可能导致AD的认知障碍。因此，更好地了解血脑屏障破裂引起的血管功能障碍如何与淀粉样蛋白-β和tau AD生物标志物相互作用，从而导致认知障碍，可能会为研究发病机制提供新的思路，并可能治疗和预防早期认知障碍，痴呆和AD，我们仍然没有有效的治疗方法。
Vascular dysfunction is frequently seen in disorders associated with cognitive impairment, dementia and Alzheimer’s disease (AD). Recent advances in neuroimaging and fluid biomarkers suggest that vascular dysfunction is not an innocent bystander only accompanying neuronal dysfunction. Loss of cerebrovascular integrity, often referred to as breakdown in the blood-brain barrier (BBB), has recently shown to be an early biomarker of human cognitive dysfunction and possibly underlying mechanism of age-related cognitive decline. Damage to the BBB may initiate or further invoke a range of tissue injuries causing synaptic and neuronal dysfunction and cognitive impairment that may contribute to AD. Therefore, better understanding of how vascular dysfunction caused by BBB breakdown interacts with amyloid-β and tau AD biomarkers to confer cognitive impairment may lead to new ways of thinking about pathogenesis, and possibly treatment and prevention of early cognitive impairment, dementia and AD, for which we still do not have effective therapies.