Regional body composition as a determinant of arterial stiffness in the elderly: The Hoorn Study
Regional body composition as a determinant of arterial stiffness in the elderly: The Hoorn Study
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DOI：
10.1097/00004872-200412000-00016
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发表时间：
2004-12-01
影响因子：
4.9
通讯作者：
Stehouwer, CDA
中科院分区：
文献类型：
--
作者：
Snijder, MB;Henry, RMA;Stehouwer, CDA
目的 评估精确测量的老年人局部身体成分与外周和中央动脉僵硬度的关系。 方法 我们调查了 Hoorn 研究（一项基于人群的队列研究）的 648 名参与者（平均年龄 69.0 +/- 6.0 岁）。通过双能X射线骨密度仪区分躯干脂肪、腿部脂肪、躯干瘦肉和腿部瘦肉质量。我们使用超声波来测量颈动脉、股动脉和肱动脉的扩张性和顺应性，以及颈动脉杨氏弹性模量，作为外周僵硬度的估计。作为中央僵硬度的估计，我们测量了颈动脉-股动脉传输时间、主动脉增强指数和全身动脉顺应性。结果在对性别、年龄、身高、平均动脉压、腿瘦和腿部脂肪量进行调整后，较大的躯干脂肪量始终与较高的外周动脉僵硬度相关（所有三个大动脉的平均 Z 分数的标准化 beta (β) -0.24，P
Objective To estimate the relation of precisely measured regional body composition with peripheral and central arterial stiffness in the elderly.Methods We investigated 648 participants (mean age 69.0 +/- 6.0 years) of the Hoorn Study, a population-based cohort study. Trunk fat, leg fat, trunk lean and leg lean mass were distinguished by dual-energy X-ray absorptiometry. We used ultrasound to measure the distensibility and compliance of the carotid, femoral and brachial arteries, and carotid Young's elastic modulus, as estimates of peripheral stiffness. As estimates of central stiffness we measured carotid-femoral transit time, aortic augmentation index and systemic arterial compliance.Results After adjustment for sex, age, height, mean arterial pressure, leg lean and leg fat mass, a larger trunk fat mass was consistently associated with higher peripheral arterial stiffness (standardized beta (beta) of mean Z-scores of all three large arteries -0.24, P