The genomic and functional landscapes of developmental plasticity in the American cockroach
The genomic and functional landscapes of developmental plasticity in the American cockroach
复制标题
美洲大蠊发育可塑性的基因组和功能景观
DOI：
10.1038/s41467-018-03281-1
复制
发表时间：
2018-03-20
影响因子：
16.6
通讯作者：
Zhan, Shuai
中科院分区：
文献类型：
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作者：
Li, Sheng;Zhu, Shiming;Zhan, Shuai
许多蟑螂物种已经适应了城市环境，有些已经成为热带和亚热带地区公共卫生的严重害虫。在这里，我们提出了3.38-Gb的基因组和美国蟑螂，美洲大蠊的共识基因集。我们报告的见解，从基因组和功能的调查，其适应城市环境和发展的可塑性的基础。与其它昆虫相比，黑腹小蜂基因家族的扩展性更强。在美国，大多数核心基因家族可能与环境适应有关，如化学感受和解毒。调节变态发育的多种途径是保守的，RNAi实验告知20-羟基蜕皮激素，保幼激素，胰岛素和decapentaplegic信号在调节可塑性中的关键作用。我们的分析揭示了美国蟑螂和两种白蚁之间的基因序列高度一致性，推进它作为一个有价值的模式，研究蟑螂和白蚁之间的进化关系。
Many cockroach species have adapted to urban environments, and some have been serious pests of public health in the tropics and subtropics. Here, we present the 3.38-Gb genome and a consensus gene set of the American cockroach,Periplaneta americana. We report insights from both genomic and functional investigations into the underlying basis of its adaptation to urban environments and developmental plasticity. In comparison with other insects, expansions of gene families inP. americanaexist for most core gene families likely associated with environmental adaptation, such as chemoreception and detoxification. Multiple pathways regulating metamorphic development are well conserved, and RNAi experiments inform on key roles of 20-hydroxyecdysone, juvenile hormone, insulin, and decapentaplegic signals in regulating plasticity. Our analyses reveal a high level of sequence identity in genes between the American cockroach and two termite species, advancing it as a valuable model to study the evolutionary relationships between cockroaches and termites.