Compare and contrast the reaction coordinate diagrams for chemical reactions and cytoskeletal force generators.
Compare and contrast the reaction coordinate diagrams for chemical reactions and cytoskeletal force generators.
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DOI：
10.1091/mbc.e12-07-0545
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发表时间：
2013-02
影响因子：
3.3
通讯作者：
Scholey JM
中科院分区：
文献类型：
--
作者：
Scholey JM
反应坐标图用于将化学过程中发生的自由能变化与过程的速率和平衡常数联系起来。在这里，我简要地回顾了这些图表的热力学和动力学的产生力和运动的细胞骨架马达和聚合物棘轮，因为它们介导的细胞内运输，细胞器动力学，细胞运动和细胞分裂。为了提供一个熟悉的生化背景下，讨论这些亚细胞力发生器，我首先回顾应用反应坐标图的机制，简单的化学和酶催化反应。相对于我使用和引用的许多参考文献中的严格的生物物理处理，我对电机和聚合物棘轮的反应坐标图的描述是简化的，但我希望本文提供了一个有价值的定性表示的物理化学参数，这些参数是在分子尺度上产生力和运动的基础。在任何情况下，我发现这种方法代表了一个有用的跨学科框架，用于理解，研究和教学的基本分子机制，电机有助于基本的细胞生物学过程。
Reaction coordinate diagrams are used to relate the free energy changes that occur during the progress of chemical processes to the rate and equilibrium constants of the process. Here I briefly review the application of these diagrams to the thermodynamics and kinetics of the generation of force and motion by cytoskeletal motors and polymer ratchets as they mediate intracellular transport, organelle dynamics, cell locomotion, and cell division. To provide a familiar biochemical context for discussing these subcellular force generators, I first review the application of reaction coordinate diagrams to the mechanisms of simple chemical and enzyme-catalyzed reactions. My description of reaction coordinate diagrams of motors and polymer ratchets is simplified relative to the rigorous biophysical treatment found in many of the references that I use and cite, but I hope that the essay provides a valuable qualitative representation of the physical chemical parameters that underlie the generation of force and motility at molecular scales. In any case, I have found that this approach represents a useful interdisciplinary framework for understanding, researching, and teaching the basic molecular mechanisms by which motors contribute to fundamental cell biological processes.