Ethanol disrupts fear conditioning in C57BL/6 mice
Ethanol disrupts fear conditioning in C57BL/6 mice
复制标题
DOI：
10.1177/0269881103017001702
复制
发表时间：
2003-03-01
影响因子：
4.1
通讯作者：
Gould, TJ
中科院分区：
文献类型：
--
作者：
Gould, TJ
乙醇已被证明会破坏多种形式的学习。例如，乙醇破坏了老鼠的恐惧条件反射。令人惊讶的是，小鼠报告了相反的结果。由于小鼠模型在乙醇研究中的重要性和C57 BL/6背景下产生的转基因小鼠的优势，本研究探讨了急性乙醇给药对C57 BL/6小鼠恐惧条件反射的影响。选择恐惧条件反射是因为小鼠和大鼠之间的结果存在明显的矛盾，因为它在评估前脑依赖性学习中的流行性，并且因为该任务考察了两种类型的学习：（i）依赖于大脑皮层的情境学习和（ii）独立于大脑皮层的条件刺激-非条件刺激学习。生成了在训练日、测试日或两天给予乙醇（0.5、1.0和1.5 g/kg）的剂量-反应曲线。乙醇，以剂量依赖的方式，干扰恐惧条件反射时，给予训练日或训练和测试日。仅在测试日给予乙醇不会破坏恐惧条件反射。目前的结果表明，乙醇破坏C57 BL/6小鼠的恐惧条件反射。
Ethanol has been demonstrated to disrupt numerous forms of learning. For example, ethanol disrupts fear conditioning in rats. Surprisingly, the opposite result was reported for mice. Because of the importance of mouse models in ethanol research and the predominance of transgenic mice generated on a C57BL/6 background, the present study examined the effects of acute ethanol administration on fear conditioning in C57BL/6 mice. Fear conditioning was chosen because of the apparent contradiction in results between mice and rats, because of its popularity in assessing forebrain-dependent learning and because the task examines two types of learning: (i) the hippocampus-dependent contextual learning and (ii) the hippocampus-independent conditioned stimulus-unconditioned stimulus learning. Dose-response curves were generated for ethanol (0.5, 1.0 and 1.5 g/kg) given on either training day, testing day, or both days. Ethanol, in a dose-dependent manner, disrupted fear conditioning when given on training day or given on both training and testing days. Ethanol given on testing day only did not disrupt fear conditioning. The present results demonstrate that ethanol disrupts fear conditioning in C57BL/6 mice.