Genetic diversities of 20 novel autosomal STRs in Chinese Xibe ethnic group and its genetic relationships with neighboring populations
Genetic diversities of 20 novel autosomal STRs in Chinese Xibe ethnic group and its genetic relationships with neighboring populations
复制标题
中国锡伯族20种新常染色体STR遗传多样性及其与邻近人群的遗传关系
DOI：
10.1016/j.gene.2014.12.037
复制
发表时间：
2015-02-25
期刊：
影响因子：
3.5
通讯作者：
Zhu, Bo-Feng
中科院分区：
文献类型：
--
作者：
Meng, Hao-Tian;Zhang, Li-Ping;Zhu, Bo-Feng
本研究调查了中国锡伯族20个新的STR基因座和一个先前研究过的基因座的遗传多态性，以及其与邻近人群的遗传关系。226名锡伯族无血缘关系的健康个体参与研究。每个位点至少有5个等位基因，最小和最大等位基因频率分别为0.0022和0.5221。我们分别在D1S1627和D19S433位点获得了最低和最高的观察杂合性和预期杂合性。所有21个STR基因座的综合鉴别力和排除概率分别为0.9999999999999997310和0.9999998650。群体间分化、主成分分析、遗传距离和系统发育树分析揭示了锡伯族与邻近群体的亲缘关系，表明锡伯族与蒙古族的亲缘关系较近。结果表明，这21个STR基因座在锡伯族群体中具有较高的遗传多态性，可用于法医学亲子鉴定和个体识别。(C)2014爱思唯尔有限公司版权所有。
In the present study, we investigated the genetic polymorphisms of 20 novel STR loci and one previously studied locus in the Xibe ethnic group from China, as well as its genetic relationships with neighboring populations. Totally 226 unrelated healthy Xibe individuals were involved in the study. At least 5 alleles were observed for each locus, with the minimum and maximum allelic frequencies of 0.0022 and 0.5221, respectively. We obtained the lowest and highest observed heterozygosity and expected heterozygosity at locus D1S1627 and D19S433, respectively. The values of combined power of discrimination and probability of exclusion of all the 21 STR loci were 0.99999999999999999997310 and 0.999998650, respectively. Analyses of interpopulation differentiation, principal component analysis, genetic distance and phylogenetic tree revealed the relationships between Xibe group and its neighboring groups, showing that the studied Xibe group had a close genetic relationship with the Mongolian group. The present results indicated that these 21 STR loci had high genetic polymorphisms in the studied Xibe group, and were capable for the paternity testing and individual identification in forensic application. (C) 2014 Elsevier B.V. All rights reserved.