Prefrontal regional correlates of self-control in male psychiatric patients: Impulsivity facets and aggression
Prefrontal regional correlates of self-control in male psychiatric patients: Impulsivity facets and aggression
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DOI：
10.1016/j.pscychresns.2010.09.003
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发表时间：
2011-01-30
影响因子：
2.3
通讯作者：
Fulwiler, Carl
中科院分区：
文献类型：
--
作者：
Gansler, David A.;Lee, Athene K. W.;Fulwiler, Carl
研究前额叶皮层（PFC）中攻击性和冲动性特征的组织可以增进我们对自我控制的神经心理生物学的理解。虽然 PFC (OFC) 的轨道方面已受到关注，但有理由相信横向方面也相关。在目前使用磁共振成像的研究中，侧位 PFC (LPFC) 中的灰质体积是从异质男性精神病样本 (N = 36) 中得出的，其中 OFC 体积先前已报告过。在使用冲动性和攻击性特质的自我报告测量进行的分析中，左 LPFC 解释了冲动性的注意力方面（13％）和攻击性（10％）的显着差异，但没有解释假设的冲动性的运动方面。 OFC 与运动冲动相关（左 20%；右 14%），并且与攻击性相关（左 36%；右 16%）。根据 LPFC 或 OFC 与攻击性和冲动性特质的关联是否相互依赖，探索了一种社会/情感信息处理模型。结果表明，LPFC 与攻击性和注意力冲动的关联取决于 OFC，而反之则不受支持。 LPFC 似乎与皮质自我控制网络的高阶方面相关，并且这种相关性取决于 OFC 的强大贡献。 (C) 2010 Elsevier Ireland Ltd. 保留所有权利。
Investigating the organization of trait aggression and impulsivity in the prefrontal cortex (PFC) advances our understanding of the neuropsychobiology of self-control. While the orbital aspect of the PFC (OFC) has received attention, there is reason to believe the lateral aspect is also relevant. In the current study using magnetic resonance imaging, gray matter volumes in lateral PFC (LPFC) were derived in a heterogeneous male psychiatric sample (N = 36) in which OFC volumes had previously been reported. In an analysis using self-report measures of trait impulsivity and aggression, the left LPFC accounted for significant variance in attentional aspects of impulsivity (13%) and aggression (10%) but not motor aspects of impulsivity, as hypothesized. The OFC was associated with motor impulsivity (left-20%; right-14%) and was also more robustly associated with aggression (left-36%; right-16%). A social/emotional information processing model was explored, based upon whether the LPFC or the OFC depended upon one another for their association to trait aggression and impulsivity. It was demonstrated that association of the LPFC to both aggression and attentional impulsivity depended upon the OFC, while the converse was not supported. The LPFC appears relevant to the higher-order aspects of a cortical self-control network, and that relevance is dependent upon the robust contribution of the OFC. (C) 2010 Elsevier Ireland Ltd. All rights reserved.