A Mock Circulation Loop for In Vitro Hemodynamic Evaluation of Aorta: Application in Aortic Dissection
A Mock Circulation Loop for In Vitro Hemodynamic Evaluation of Aorta: Application in Aortic Dissection
复制标题
用于主动脉体外血流动力学评估的模拟循环回路：在主动脉夹层中的应用
DOI：
10.1177/15266028211034863
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发表时间：
2021-08-03
影响因子：
2.6
通讯作者：
Xiong, Jiang
中科院分区：
文献类型：
--
作者：
Chen, Duanduan;Liang, Shichao;Xiong, Jiang
目的主动脉夹层（AD）是一种血流动力学复杂的灾难性疾病，但对其血流灌注特性的认识还不够充分。在这项研究中，提出了一种模拟循环回路（MCL），该回路集成了Windkessel元件和患者特定的硅胶主动脉体模，以在体外重现主动脉血流环境。材料与方法建立具有12支分支血管的正常和夹层主动脉模型，并将其嵌入MCL。以20例健康志愿者的主动脉分支速度作为分流的标准化数据。通过改变边界条件，所提出的MCL可以模拟正常静息和左侧心力衰竭（LHF）条件。主动脉分支的流速和压力状态可以通过单独的传感器量化。结果在正常静息状态下，模拟心率为60次/分，体循环流速为4.85 L/min。对于LHF条件，收缩压和舒张压分别为75.94 +/- 0.77 mmHg和57.65 +/- 0.35 mmHg。通过调节血管顺应性和外周阻力，每个主动脉分支的流量分配比（FDR）通过正常主动脉体模的标准化数据（平均差异2.4% ± 1.70%）进行验证。通过比较正常和夹层主动脉模型在静息状态下的结果，我们的结果表明，AD模型表现出更高的收缩压，（117.82 +/- 0.60 vs 108.75 +/- 2.26 mmHg）和舒张压（72.38 +/- 0.58 vs 70.46 +/- 2.33 mmHg）压力，真腔中的时间平均流速假腔内的血流速度（TL; 36.95 cm/s）高于假腔内的血流速度（FL; 22.95 cm/s），并且在不同的折返点，TL和FL之间的血流输送方向不同。结论MCL可用于各种物理条件下主动脉病变的体外血流动力学分析。
Purpose Aortic dissection (AD) is a catastrophic disease with complex hemodynamic conditions, however, understandings regarding its perfusion characteristics were not sufficient. In this study, a mock circulation loop (MCL) that integrated the Windkessel element and patient-specific silicone aortic phantoms was proposed to reproduce the aortic flow environment in vitro. Materials and Methods Patient-specific normal and dissected aortic phantoms with 12 branching vessels were established and embedded into this MCL. Velocities for aortic branches based on 20 healthy volunteers were regarded as the standardized data for flow division. By altering boundary conditions, the proposed MCL could mimic normal resting and left-sided heart failure (LHF) conditions. Flow rates and pressure status of the aortic branches could be quantified by separate sensors. Results In normal resting condition, the simulated heart rate and systemic flow rate were 60 bpm and 4.85 L/minute, respectively. For the LHF condition, the systolic and diastolic blood pressures were 75.94 +/- 0.77 mmHg and 57.65 +/- 0.35 mmHg, respectively. By tuning the vascular compliance and peripheral resistance, the flow distribution ratio (FDR) of each aortic branch was validated by the standardized data in the normal aortic phantom (mean difference 2.4%+/- 1.70%). By comparing between the normal and dissected aortic models under resting condition, our results indicated that the AD model presented higher systolic (117.82 +/- 0.60 vs 108.75 +/- 2.26 mmHg) and diastolic (72.38 +/- 0.58 vs 70.46 +/- 2.33 mmHg) pressures, the time-average velocity in the true lumen (TL; 36.95 cm/s) was higher than that in the false lumen (FL; 22.95 cm/s), and the blood transport direction between the TL and FL varied in different re-entries. Conclusions The proposed MCL could be applied as a research tool for in vitro hemodynamic analysis of the aorta diseases under various physical conditions.