Clinical implications of 18F-sodium fluoride uptake in subclinical aortic valve calcification: Its relation to coronary atherosclerosis and its predictive value
Clinical implications of 18F-sodium fluoride uptake in subclinical aortic valve calcification: Its relation to coronary atherosclerosis and its predictive value
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DOI：
10.1007/s12350-019-01879-6
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发表时间：
2021-08-01
影响因子：
2.4
通讯作者：
Kihara, Yasuki
中科院分区：
文献类型：
--
作者：
Nakamoto, Yumiko;Kitagawa, Toshiro;Kihara, Yasuki
背景 正电子发射断层扫描 (PET) 上 F-18-氟化钠 (F-18-NaF) 的摄取反映了活动性钙化。该技术在主动脉瓣钙化（AVC）早期的应用具有临床意义。我们研究了与冠状动脉粥样硬化同时评估的亚临床 AVC 中 F-18-NaF 摄取的临床意义，以及 F-18-NaF 摄取在预测 AVC 进展中的效用。方法 我们研究了 25 名接受 F-18-NaF PET/CT 治疗的亚临床 AVC 和计算机断层扫描 (CT) 检测到冠状动脉斑块的患者。通过 CT 评估每位患者的 AVC 评分、体积、平均密度和高危冠状动脉斑块的存在情况。 AVC 和冠状动脉斑块中的局部 F-18-NaF 摄取通过最大组织与背景比 (TBRmax) 进行量化。结果AVC TBRmax（A-TBRmax）与CT上AVC参数呈正相关。 14 名有高危冠状动脉斑块的患者的 A-TBRmax 显着高于无此类斑块的患者（分别为 1.60 +/- 0.18 和 1.42 +/- 0.13；P = 0.012）。 A-TBRmax 与每位患者冠状动脉斑块的最大 TBRmax 呈正相关（r = 0.55，P = 0.0043）。在接受随访 CT 扫描的 11 名患者中，A-TBRmax 与随后 AVC 评分的增加呈正相关（r = 0.74，P = 0.0091）。结论 我们基于 F-18-NaF PET 和 CT 的数据表明亚临床 AVC 钙化活动与冠状动脉粥样硬化特征之间的关系。 F-18-NaF PET 可能提供有关亚临床 AVC 的分子状况和未来进展的新信息。
Background Uptake of F-18-sodium fluoride (F-18-NaF) on positron emission tomography (PET) reflects active calcification. Application of this technique in the early phase of aortic valve calcification (AVC) is of clinical interest. We investigated clinical implications of F-18-NaF uptake in subclinical AVC evaluated simultaneously with coronary atherosclerosis, and the utility of F-18-NaF uptake in predicting AVC progression. Methods We studied 25 patients with subclinical AVC and coronary plaques detected on computed tomography (CT) who underwent F-18-NaF PET/CT. AVC score, volume, mean density, and the presence of high-risk coronary plaque were evaluated on CT in each patient. Focal F-18-NaF uptake in AVC and in coronary plaques was quantified with the maximum tissue-to-background ratio (TBRmax). Results There were positive correlations between AVC TBRmax (A-TBRmax) and AVC parameters on CT. The 14 patients with high-risk coronary plaque had significantly higher A-TBRmax than those without such plaque (1.60 +/- 0.18 vs 1.42 +/- 0.13, respectively; P = 0.012). A-TBRmax positively correlated with maximum TBRmax of coronary plaque per patient (r = 0.55, P = 0.0043). In the 11 patients who underwent follow-up CT scan, A-TBRmax positively correlated with subsequent increase in AVC score (r = 0.74, P = 0.0091). Conclusion Our F-18-NaF PET- and CT-based data indicate relationships between calcification activity in subclinical AVC and characteristics of coronary atherosclerosis. F-18-NaF PET may provide new information regarding molecular conditions and future progression of subclinical AVC.