Plasticity in the nervous system of adult hydra. I. The position-dependent expression of FMRFamide-like immunoreactivity.
Plasticity in the nervous system of adult hydra. I. The position-dependent expression of FMRFamide-like immunoreactivity.
复制标题
成年水螅神经系统的可塑性。
DOI：
10.1016/0012-1606(86)90142-9
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发表时间：
1986
影响因子：
2.7
通讯作者：
Bode,HR
中科院分区：
文献类型：
--
作者：
Koizumi,O;Bode,HR
在成年水螅中检测了表达神经肽FMRFamide的神经细胞的可塑性。使用间接免疫荧光整体封片技术，显示FMRFamide样免疫反应性（FLI）的神经元的空间模式可视化。这些神经元分布于触角、下体和脚，而不分布于体柱和基盘。由于神经网络中的每个神经元都不断地向末端移位并最终脱落，因此FLI+神经元的恒定模式可能以两种方式之一出现。当移位到适当的区域时，FLI−神经元转化为FLI+神经元，或者FLI+神经元由间质细胞分化而产生。为了区分这两种可能性，间质细胞，神经细胞的多能前体，被清除的治疗与羟基脲或氮芥。从这些动物的头或脚和脚梗移除后，缺失的结构再生。FLI+神经元的空间分布在新生的头或脚中重现。这表明，当体柱中的FLI−神经元的位置改变到头部或脚时，它们被转换为FLI+。当蒂部移植到体柱后，它转变为基底盘或体柱组织，FLI消失。FLI的出现和消失总是位置依赖性的。这些结果表明，成熟神经网中的神经元可以改变其神经肽表型，以响应其位置的变化。
The plasticity of nerve cells expressing the neuropeptide FMRFamide was examined in adult hydra. Using a whole-mount technique with indirect immunofluorescence, the spatial pattern of neurons showing FMRFamide-like immunoreactivity (FLI) was visualized. These neurons were located in the tentacles, hypostome, and peduncle, but not in the body column or basal disc. Since every neuron in the nerve net is continuously displaced toward an extremity and eventually sloughed, the constant pattern of FLI+neurons could arise in one of two ways. When displaced into the appropriate region, FLI−neurons are converted to FLI+neurons, or FLI+neurons arise by differentiation from interstitial cells. To distinguish between these two possibilities, interstitial cells, the multipotent precursors of the nerve cells, were eliminated by treatment with hydroxyurea or nitrogen mustard. Following head, or foot and peduncle, removal from these animals, the missing structures regenerated. The spatial pattern of FLI+neurons reappeared in the newly regenerated head or peduncle. This shows FLI−neurons in the body column were converted to FLI+when their position was changed to the head or the peduncle. When the peduncle was grafted into the body column, it was converted to basal disc or body column tissue, and FLI disappeared. The appearance and loss of FLI was always position dependent. These results indicate that the neurons in the mature nerve net can change their neuropeptide phenotype in response to changes in their position.
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影响因子：
1.5
作者：
CAMPBELL, RD
通讯作者：
CAMPBELL, RD
多能干细胞（水螅间质细胞）的调节。
影响因子：
3.8
作者：
Hans R. Bode;Charles N. David
通讯作者：
Charles N. David
衰减水螅间质细胞分化的调节。
影响因子：
4
作者：
H. Bode;K. Flick;G. Smith
通讯作者：
G. Smith
DOI：
--
发表时间：
1964
期刊：
The Journal of experimental zoology
影响因子：
--
作者：
F. Diehl;Allison L. Burnett
通讯作者：
Allison L. Burnett
水螅中神经肽的共存
影响因子：
3.3
作者：
C. Grimmelikhuijzen
通讯作者：
C. Grimmelikhuijzen