THE MICROTUBULE BINDING REPEATS OF TAU PROTEIN ASSEMBLE INTO FILAMENTS LIKE THOSE FOUND IN ALZHEIMERS-DISEASE
THE MICROTUBULE BINDING REPEATS OF TAU PROTEIN ASSEMBLE INTO FILAMENTS LIKE THOSE FOUND IN ALZHEIMERS-DISEASE
复制标题
DOI：
10.1016/0014-5793(92)81094-3
复制
发表时间：
1992-09-07
期刊：
影响因子：
3.5
通讯作者：
GOEDERT, M
中科院分区：
文献类型：
--
作者：
CROWTHER, RA;OLESEN, OF;GOEDERT, M
成对的螺旋丝，其中包括在阿尔茨海默氏病的神经元缠结的主要纤维元素，包含异常磷酸化的微管相关蛋白tau作为其主要成分。tau蛋白的重复区域，代表微管结合结构域，形成细丝的核心。在这里，我们表明，跨重复区域的tau蛋白表达片段可以在体外组装成细丝，就像在阿尔茨海默病中发现的那样
The paired helical filament, which comprises the major fibrous element of the neurofibrillary tangle in Alzheimer's disease, contains abnormally phosphorylated microtubule-associated protein tau as its principal constituent. The repeat region of tau protein, which represents the microtubule binding domain, forms the core of the filament. Here we show that an expressed fragment of tau protein spanning the repeat region can assemble in vitro into filaments like those found in Alzheimer's disease