Role of microRNAs in cardiac preconditioning.
Role of microRNAs in cardiac preconditioning.
复制标题
DOI：
10.1097/fjc.0b013e3181f581ba
复制
发表时间：
2010-12
影响因子：
3
通讯作者：
Kukreja RC
中科院分区：
文献类型：
--
作者：
Salloum FN;Yin C;Kukreja RC
通过亚致死性缺血、轻度热休克或缺氧对心脏进行预处理已经发展成为发现心脏保护中新的信号传导机制的有力实验工具。最终目标是确定新的治疗靶点，用于保护人类心脏免受缺血相关损伤。近年来，人们对了解小的非编码RNA（microRNA，miRs）在心血管疾病中的作用产生了极大的兴趣。miR已被认为是通过靶mRNA的去稳定化和翻译抑制来调节基因表达的调节剂。研究表明，包括miR-1、miR-133、miR-21、miR-126、miR-320、miR-92 a和miR-199 a在内的几种miR在预处理后受到调节，并在保护心脏免受缺血/再灌注损伤中发挥积极作用。这些miR还驱动重要的心脏保护蛋白的合成，包括HSP-70、eNOS、iNOS、HSP-20、Sirt-1和HIF-1α。我们相信，在心脏中识别和靶向递送miR（s）在减少患有心脏病的患者的心肌梗死方面可能具有巨大的治疗潜力。
Preconditioning of the heart by sub-lethal ischemia, mild heat shock or hypoxia have evolved as powerful experimental tools to discover novel signaling mechanisms in cardioprotection. The ultimate goal is to determine novel therapeutic targets for potential application in humans in protecting the heart against ischemia-related injuries. In recent years, there has been a tremendous interest in understanding the role of small non-coding RNAs, microRNAs (miRs), in cardiovascular diseases. miRs have been recognized as regulators of gene expression by destabilization and translational inhibition of target mRNAs. Studies have shown that several miRs including miR-1, miR-133, miR-21, miR-126, miR-320, miR-92a and miR-199a are regulated after preconditioning and play an active role in protection of the heart against ischemia/reperfusion injury. These miRs also drive the synthesis of important cardioprotective proteins including HSP-70, eNOS, iNOS, HSP-20, Sirt-1 and HIF-1α. We believe that identification and targeted delivery of miR(s) in the heart could have an immense therapeutic potential in reducing myocardial infarction in patients suffering from heart disease.