Physical activity, heart rate, metabolic profile, and estradiol in premenopausal women
Physical activity, heart rate, metabolic profile, and estradiol in premenopausal women
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DOI：
10.1249/mss.0b013e318167411f
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发表时间：
2008-06-01
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影响因子：
--
通讯作者：
Thune, Inger
中科院分区：
文献类型：
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作者：
Emaus, Aina;Veierod, Marit B.;Thune, Inger
目的：研究有代谢综合征倾向的缺乏体力活动的女性是否具有高水平的17β-雌二醇(E-2)，这对乳腺癌风险具有重要意义。方法：对200名健康育龄妇女进行自我报告的闲暇体力活动(LPA)、静息心率(HR)、血压(BP)、人体测量、血糖、血脂和胰岛素[挪威能量平衡与乳腺癌方面(EBBA)研究]。在整个月经周期中，每天的唾液样本中都检测到了E-2。定义聚集性代谢风险评分[z代谢综合征(ZMS)；总胆固醇-高密度脂蛋白-胆固醇(HDLC)比率、胰岛素抵抗、总脂肪组织、血压和甘油三酯]。采用线性回归和线性混合模型，并对混杂因素进行检验。结果：运动女性的脂肪百分比(P-趋势=0.003)和心率(P-趋势=0.003)均低于久坐女性。我们估计，心率每增加11.7次·分(-1)(1SD)，E-2增加1.27pmol.L-1[95%可信区间(CI)，0.06-2.47]，这对应于整个组E-2平均浓度变化7%。脂肪组织、总胆固醇-高密度脂蛋白胆固醇比率、胰岛素抵抗和甘油三酯也与E-2相关。LPA与HR、ZMS之间存在剂量-反应关系(LPA P趋势=0.03，HR P趋势=0-004)。在整个周期中，新陈代谢风险得分最高的三分位数女性的唾液E-2平均值明显高于其他组，E-2的周期峰值日差值为22-28%。结论：LPA和HR与代谢风险评分相关，该评分与每日E-2水平相关，表明久坐的生活方式与乳腺癌风险增加之间存在重要的生物学机制。
Purpose: To study whether physical inactive women with a tendency to develop metabolic syndrome have high levels of 17 beta-estradiol (E-2) of importance for breast cancer risk. Methods: Two hundred and fur healthy women of reproductive age were assessed for self-reported leisure-time physical activity (LPA), resting heart rate (HR), blood pressure (BP), anthropometry, and serum glucose, lipids, and insulin [Norwegian Energy Balance and Breast Cancer Aspect (EBBA) study]. E-2 was measured in daily saliva samples throughout an entire menstrual cycle. A clustered metabolic risk score [z metabolic syndrome (zMS); total cholesterol-high-density lipoprotein-cholesterol (HDL-C) ratio, insulin resistance, total fat tissue, BP, and triglycerides] was defined. Linear regression and linear mixed models were used, and confounding factors were tested. Results: Physically active women had lower fat percentage (P-trend = 0.003) and HRs (P-trend = 0.003) than sedentary women. We estimated an increase in E-2 of 1.27 pmol.L-1 [95% confidence interval (CI), 0.06-2.47] for each 11.7 beats.min(-1) (1 SD) increase in HR, and this corresponds to the 7% change in mean concentration of E-2 for the total group. Associations with E-2 were also found for fat tissue, total cholesterol-HDL-C ratio, insulin resistance, and triglycerides. A dose-response relationship was observed among the three levels of LPA and HR and zMS (P-trend = 0.03 for LPA; P-trend = 0-004 for HR). Women in the highest tertile of the clustered metabolic risk score had average salivary E-2 profiles that were markedly higher, throughout the cycle, than those of the other groups, with a cycle peak-day difference in E-2 of 22-28%. Conclusion: LPA and HR were associated with metabolic risk score, and this score was associated with daily level of E-2, pointing to important biologic mechanisms operating between a sedentary lifestyle and an increased breast cancer risk.