A case of suicide by ingestion of caffeine
A case of suicide by ingestion of caffeine
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DOI：
10.1007/s12024-014-9571-6
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发表时间：
2014-09-01
影响因子：
1.8
通讯作者：
Palmiere, Cristian
中科院分区：
文献类型：
--
作者：
Bonsignore, Alessandro;Sblano, Sara;Palmiere, Cristian
由于过量摄入含有咖啡因的饮料或能量饮料而故意或无意地滥用咖啡因的情况相对频繁。然而，咖啡因中毒致死的情况很少见，咖啡因中毒致死的病例报告也相对较少。在这份报告中，我们描述了一起尸检案件，涉及一名31岁的男子，他故意服用大量咖啡因片剂作为减肥补充剂，作为自杀计划的一部分。在类似病例中，咖啡因的股动脉血浓度(170毫克/L)在文献报道的毒性和潜在致死范围内。死后生化结果显示死亡时肾小球滤过率降低和肾前性衰竭，但没有发现肌红蛋白尿、血糖尿、酮尿症或酮血症。根据尸检没有病理发现和血液中咖啡因水平较高，死亡被归因于急性咖啡因中毒。该案强调进行详尽的毒物学和搜索所有可能相关的信息，以便就死亡原因和方式提出适当的假设是有用的。
Intentional or unintentional caffeine abuse due to excessive intake of beverages or energy drinks containing caffeine is relatively frequent. However, death due to caffeine intoxication is rare and case reports of fatalities from caffeine toxicity are relatively infrequent. In this report, we describe an autopsy case involving a 31 year-old man who intentionally took a large amount of caffeine tablets in the form of a weight loss supplement as part of a suicide plan. Caffeine femoral blood concentration (170 mg/l) was within the toxic and potentially lethal ranges reported in the literature in similar cases. Postmortem biochemistry results suggested depressed glomerular filtration rate and pre-renal failure at the time of death but failed to reveal myoglobinuria, glycosuria, ketonuria or ketonemia. Based on the absence of pathological findings at autopsy and the high blood caffeine level, death was attributed to acute caffeine toxicity. The case emphasizes the usefulness of performing exhaustive toxicology and searching for all potentially relevant information in order to formulate appropriate hypotheses concerning the cause and manner of death.