The Na+/H+ exchanger isoform 1
The Na+/H+ exchanger isoform 1
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DOI：
10.1016/j.biocel.2004.02.006
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发表时间：
2005-01-01
影响因子：
4
通讯作者：
Fliegel, L
中科院分区：
文献类型：
--
作者：
Fliegel, L
Na+/H+交换器（NHE）同种型1是一种广泛表达的整合膜蛋白，其在哺乳动物细胞中调节细胞内pH。已鉴定出Na+/H+交换剂的九种亚型。首次发现的同种型具有两个结构域：含有约500个氨基酸的N-末端膜结构域和含有约315个氨基酸的C-末端调节结构域。存在于质膜中的交换剂将细胞内质子交换为细胞外钠，从而调节细胞内pH。它参与细胞生长和分化、细胞迁移和钠通量的调节。Na ~+/H ~+交换在心肌缺血再灌注损伤中起重要作用，最近被认为是心肌肥厚的介质。目前正在开发Na+/H+交换剂的抑制剂，并正在进行临床试验，这些抑制剂可能被证明可用于这些病症的临床治疗。(C)2004爱思唯尔有限公司保留所有权利。
The Na+/H+ exchanger (NHE) isoform 1 is a ubiquitously expressed integral membrane protein which regulates intracellular pH in mammalian cells. Nine isoforms of the Na+/H+ exchanger have been identified. The isoform first discovered has two domains: an N-terminal membrane domain containing approximately 500 amino acids and a C-terminal regulatory domain containing approximately 315 amino acids. The exchanger, which resides in the plasma membrane, exchanges an intracellular proton for an extracellular sodium, thereby regulating intracellular pH. It is involved in cell growth and differentiation, cell migration, and regulation of sodium fluxes. The Na+/H+ exchanger plays an important role in myocardial damage during ischemia and reperfusion and has recently been implicated Lis a mediator of cardiac hypertrophy. Inhibitors of the Na+/H+ exchanger, which may prove useful in the clinical treatment of these conditions, are currently being developed and clinical trials are underway. (C) 2004 Elsevier Ltd. All rights reserved.