Evaluation of Artemisia annua infusion efficacy for the treatment of malaria in Plasmodium chabaudi chabaudi infected mice
Evaluation of Artemisia annua infusion efficacy for the treatment of malaria in Plasmodium chabaudi chabaudi infected mice
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DOI：
10.1016/j.exppara.2009.04.004
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发表时间：
2009-08-01
影响因子：
2.1
通讯作者：
Plaizier-Vercammen, Jacqueline
中科院分区：
文献类型：
--
作者：
Atemnkeng, Magnus A.;Chimanuka, Bantuzeko;Plaizier-Vercammen, Jacqueline
青蒿素（AR）抗疟疾的功效促使其在流行社区中被用作茶饮料。然而，对其这种形式的功效存在争议。因此，我们研究了青蒿输液对感染小鼠的有效性。感染 Chabaudi chabaudi 疟原虫的 OF1 小鼠接受以下治疗长达 6 天：水（对照组）、青蒿输液（茶组）、0.022 mg AR（AR 等效组）和第一天 0.8 mg AR，第二天 0.4 mg（AR-WHO 组）。所有组的寄生虫血症均增加。第 4 天，对照组达到 75%，AR 等效值达到 72%。组中，茶组中占 50%，AR-WHO 组中占 3%。用青蒿茶治疗的小鼠在 11 天后死亡。而AR-WHO剂量的83%存活下来。茶不能足够快地降低寄生虫血症。我们建议，有必要对人体进行大型临床试验，以确定标准化茶的功效。此外，还建议了其他治疗可能性。 (C) 2009 Elsevier Inc. 保留所有权利
The efficacy of artemisinin (AR) against malaria has prompted its use as a tea drink in endemic communities. However, there is controversy about its efficacy in this form. Therefore we have investigated the effectiveness of Artemisia annua infusion in infected mice.OF1 mice infected with Plasmodium chabaudi chabaudi were treated for upto 6 days by administration of: water (control group), A. annua infusion (tea group), 0.022 mg AR (AR-equiv. group) and 0.8 mg AR on the first day and 0.4 mg the following day (AR-WHO group).Initially, the parasitaemia increased in all groups. On day 4 it reached 75% in the control group, 72% in the AR-equiv. group, 50% in the tea group and 3% in the AR-WHO group. Mice treated with A. annua tea died after 11 days. while 83% of AR-WHO dose survived.The tea does not decrease the parasitaemia fast enough. We suggest that large clinical trials on human subjects are necessary to ascertain the efficacy of standardized tea. Additionally, other treatment possibilities are suggested. (C) 2009 Elsevier Inc. All rights reserved