Clinicopathologic significance of legumain overexpression in cancer: a systematic review and meta-analysis.
Clinicopathologic significance of legumain overexpression in cancer: a systematic review and meta-analysis.
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癌症中legumain过度表达的临床病理意义：系统评价和荟萃分析
DOI：
10.1038/srep16599
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发表时间：
2015-11-26
影响因子：
4.6
通讯作者：
Rong X
中科院分区：
文献类型：
--
作者：
Zhen Y;Chunlei G;Wenzhi S;Shuangtao Z;Na L;Rongrong W;Xiaohe L;Haiying N;Dehong L;Shan J;Xiaoyue T;Rong X
由于关于legumain在癌症中的临床意义的报道显示出不一致的结果，我们系统地评估了legumain在癌症中的临床指标。我们使用“legumain”和（“肿瘤”或“癌症”）作为检索词检索了中国的Cochrane图书馆、PubMed、Embase和EBSCO数据库以及万方和CNKI数据库。我们纳入了legumain 和癌症的病例对照研究。使用利希滕斯坦指南评估研究质量，并提取有效数据进行分析。本研究总共纳入 10 篇文章。荟萃分析显示，与正常组织相比，legumain 在癌症中过度表达，并且在 III-IV 期疾病中表达量高于 I-II 期疾病。此外，legumain 过度表达与不良预后和临床分期相关。此外，癌症基因组图谱数据显示，在直肠癌患者中，肿瘤过度表达legumain的患者总生存期短于低表达组（P<0.05）。 Legumain 似乎与肿瘤的发展和恶化有关；因此，它有可能被开发为监测和诊断肿瘤的标记物以及治疗靶点。
Since reports on the clinical significance of legumain in cancer have shown inconsistent results, we systematically evaluated clinical indicators of legumain in cancer. We searched the Cochrane Library, PubMed, Embase, and EBSCO databases and the Wangfang and CNKI databases in China by using “legumain” and (“neoplasms” OR “cancer”) as search terms. We included case-controlled studies of legumain and cancer. The quality of the studies was evaluated by using Lichtenstein’s guidelines, and valid data was extracted for analysis. In total, 10 articles were included in this study. Meta-analysis showed that legumain was overexpressed in cancer compared with in normal tissue and was higher in stage III–IV disease than in I–II disease. Moreover, legumain overexpression was correlated with poor prognosis and clinical stage. Furthermore, Cancer Genome Atlas data showed that among patients with rectal cancer, those with tumors overexpressing legumain had shorter overall survival than those in the low expression group (P < 0.05). Legumain appears to be involved in tumor development and deterioration; thus, it can potentially be developed into both a marker for monitoring and diagnosing tumors and a therapeutic target.