The plaque "micro" environment: microRNAs control the risk and the development of atherosclerosis.
The plaque "micro" environment: microRNAs control the risk and the development of atherosclerosis.
复制标题
斑块“微”环境：microRNA 控制动脉粥样硬化的风险和发展。
DOI：
10.1007/s11883-012-0272-x
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发表时间：
2012
影响因子：
5.8
通讯作者：
Moore,KathrynJ
中科院分区：
文献类型：
--
作者：
Rayner,KateyJ;Moore,KathrynJ
虽然microRNAs的发现极大地扩展了我们对许多生物过程中基因网络调控机制的理解，但对这些微小的RNA发电站在心血管疾病中的研究还处于初级阶段。到目前为止，已经发现了1200多个人类microRNAs，据估计，它们影响到人类基因组中一半以上的蛋白质编码部分的表达。在这篇综述中，我们将讨论在影响心血管疾病危险因素的过程中不可或缺的miRNAs，以及作用于血管壁水平影响动脉粥样硬化形成的miRNAs。我们将讨论microRNAs如何不仅推动心血管生物学领域的发展，而且一些miRNAs如何处于药物开发的前沿，并可能很快进入临床。
While the discovery of microRNAs has exponentially expanded our understanding of the regulatory mechanisms governing gene networks in many biological processes, the study of these tiny RNA powerhouses in cardiovascular disease is in its infancy. To date, there have been over 1200 human microRNAs identified, and they are estimated to affect the expression of over half of the protein-coding portion of the human genome. In this review, we will discuss miRNAs that are integral players in processes affecting risk factors for CVD, as well as miRNAs that act at the level of the vessel wall to affect atherogenesis. We will discuss how microRNAs are not only advancing the field of cardiovascular biology, but how some miRNAs are at the forefront of drug development and may be soon advancing into the clinic.