Label-free biosensor by protein grating coupler on planar optical waveguides
Label-free biosensor by protein grating coupler on planar optical waveguides
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DOI：
10.1364/ol.33.001735
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发表时间：
2008-08-01
期刊：
影响因子：
3.6
通讯作者：
Bachman, Mark
中科院分区：
文献类型：
--
作者：
Lai, Zhian;Wang, Yuli;Bachman, Mark
我们报道了一种基于衍射原理的平面光波导表面无标记生物传感器。通过选择性地将蛋白质固定在光波导上，蛋白质可以形成潜像光栅的脊/谷。与图案化的表面蛋白质的结合事件动态地增加光栅高度，并导致光耦合出波导的增加。我们证明了这种策略的蛋白质检测的有效性，并提出了一种设备的设计和制造。(C)2008年美国光学学会。
We report a diffraction-based, label-free biosensor on the surface of a planar optical waveguide. By selectively immobilizing proteins on an optical waveguide, the proteins can form the ridge/valley of a latent image optical grating. Binding events with patterned surface proteins dynamically increase grating height and cause an increase in light coupling out of the waveguide. We demonstrate the efficacy of this strategy for protein detection and present the design and fabrication of a device. (C) 2008 Optical Society of America.