Photophobia, visual hallucinations, and REM sleep behavior disorder in progressive supranuclear palsy and corticobasal degeneration: A prospective study
Photophobia, visual hallucinations, and REM sleep behavior disorder in progressive supranuclear palsy and corticobasal degeneration: A prospective study
复制标题
DOI：
10.1016/j.parkreldis.2008.01.011
复制
发表时间：
2009-01-01
影响因子：
4.1
通讯作者：
Josephs, Keith A.
中科院分区：
文献类型：
--
作者：
Cooper, Alex D.;Josephs, Keith A.
进行性核上性瘫痪(PSP)和皮质基底性变性(CBD)具有重叠的临床特征，这使得临床上很难区分这两种疾病。本研究比较了临床诊断为PSP的患者和临床怀疑患有CBD的患者的畏光、幻觉和REM睡眠行为障碍(RBD)的频率。10例(100%)PSP患者与2例(18%)临床疑似CBD患者发生畏光反应(p=0.0002)。视觉幻觉和RBD在PSP和CBD患者中出现，但很少发生(每种症状都有5%)。在临床诊断的PSP中，畏光的出现明显多于CBD，在临床实践中可以作为鉴别这两种疾病的一个特征。视觉幻觉和RBD在PSP和CBD中很少见，在临床鉴别中不是有用的症状。(C)2008爱思唯尔有限公司。保留所有权利。
Progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) have overlapping clinical features that can make clinical distinction between these two entities difficult. The present study compared the frequency of photophobia, visual hallucinations, and REM sleep behavior disorder (RBD) in patients clinically diagnosed with PSP to those clinically suspected to have CBD. Photophobia Occurred in all 10 (100%) PSP patients vs 2 (18%) patients with clinically suspected CBD (p = 0.0002). Visual hallucinations and RBD occurred in patients with PSP and CBD but were rare occurrences (5% for each symptom). The presence of photophobia is significantly more frequent in clinically diagnosed PSP than CBD and can be used as a feature in differentiating between the two diseases in clinical practice. Visual hallucinations and RBD occur infrequently in PSP and CBD and are not useful symptoms in clinical differentiation. (C) 2008 Elsevier Ltd. All rights reserved.