Going global by adapting local: A review of recent human adaptation.

Going global by adapting local: A review of recent human adaptation.
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通过适应本地来进行全球:对最近的人类适应的评论。

DOI:
10.1126/science.aaf5098
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发表时间:
2016-10-07
期刊:
Science (New York, N.Y.)
影响因子:
--
通讯作者:
Tishkoff SA
Tishkoff SA
中科院分区:
其他
文献类型:
--
作者:
Fan S;Hansen ME;Lo Y;Tishkoff SA

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现代人在全球的传播导致了对不同地方环境的基因适应。基因组技术、统计分析和扩大抽样人口方面的最新发展导致改进了与适应区域生活条件和饮食习惯相关的遗传变异的识别和精细绘图。随着“组学”和古代DNA数据的日益普及,正在进行的土著人口基因组测序工作预示着我们在理解最近的人类进化以及可变特征和疾病风险的起源方面进入了一个新纪元。
The spread of modern humans across the globe has led to genetic adaptations to diverse local environments. Recent developments in genomic technologies, statistical analyses, and expanded sampled populations have led to improved identification and fine-mapping of genetic variants associated with adaptations to regional living conditions and dietary practices. Ongoing efforts in sequencing genomes of indigenous populations, accompanied by the growing availability of “-omics” and ancient DNA data, promises a new era in our understanding of recent human evolution and the origins of variable traits and disease risks.
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