Excess of allele1 for α3 subunit GABA receptor gene (GABRA3) in bipolar patients:: a multicentric association study
Excess of allele1 for α3 subunit GABA receptor gene (GABRA3) in bipolar patients:: a multicentric association study
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DOI：
10.1038/sj.mp.4000953
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发表时间：
2002-01-01
影响因子：
11
通讯作者：
Mendlewicz, J
中科院分区：
文献类型：
--
作者：
Massat, I;Souery, D;Mendlewicz, J
The available data from preclinical and pharmacological studies on the role of gamma amino butyric acid (GABA) support the hypothesis that a dysfunction in brain GABAergic system activity contributes to the vulnerability to bipolar affective disorders (BPAD). Moreover, the localization of the alpha3 subunit GABA receptor GABRA3 gene on the Xq28, a region of interest in certain forms of bipolar illness, suggests that GABRA3 may be a candidate gene in BPAD. In the present study, we tested the genetic contribution of the GABRA3 dinucleotide polymorphism in a European multicentric case-control sample, matched for sex and ethnogeographical origin. Allele and genotype (in females) frequencies were compared in 185 BPAD patients and 370 controls. A significant increase of genotype 1-1 was observed in BPAD females compared to controls (P=0.0004). Furthermore, when considering recessivity of allele 1 (females with genotype 1-1 and males carrying allele 1), results were even more significant (P=0.00002). Our findings suggest that the GABRA3 polymorphism may confer susceptibility to or may be in linkage disequilibrium with another gene involved in the genetic etiology of BPAD.
