Plasma reactive oxygen species levels are correlated with severity of age-related hearing impairment in humans
Plasma reactive oxygen species levels are correlated with severity of age-related hearing impairment in humans
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DOI：
10.1016/j.neurobiolaging.2011.10.012
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发表时间：
2012-09-01
影响因子：
4.2
通讯作者：
Liu, Tien-Chen
中科院分区：
文献类型：
--
作者：
Hwang, Juen-Haur;Chen, Jin-Cherng;Liu, Tien-Chen
研究血浆活性氧（ROS）水平与人类年龄相关性听力障碍严重程度之间的关系。我们招募了 302 名年龄在 40-77 岁之间、患有正常或对称性感音神经性听力损失的成年受试者。分析了血浆ROS水平与低频纯音平均（PTA-低）和高频纯音平均（PTA-高）的关联。鲁米诺依赖性化学发光信号反映过氧化氢 (H2O2)、次氯酸盐 (HOCl/OCl-) 和羟基自由基（中心点 OH）水平，在调整年龄、性别、中心性肥胖、全身性疾病和健康相关习惯（吸烟、饮酒、抗氧化剂摄入量）后，显示出与低 PTA 和高 PTA 呈显着正相关。光泽精依赖性化学发光信号主要反映超氧阴离子（O-2 中心点（-））水平，在调整其他变量后与 PTA-low 呈显着正相关，但与 PTA-high 不呈显着正相关。我们得出的结论是，血浆 ROS 水平与人类年龄相关的听力损伤的严重程度有关。不同的活性氧可能对听觉功能障碍产生不同的影响。 (C) 2012 Elsevier Inc. 保留所有权利。
To investigate the relationship between plasma reactive oxygen species (ROS) levels and severity of age-related hearing impairment in humans. We recruited 302 adult subjects aged 40-77 years with normal or symmetrical sensorineural hearing loss. The association of plasma ROS levels on pure tone average of low frequencies (PTA-low) and pure tone average of high frequencies (PTA-high) were analyzed. Luminol-dependent chemiluminescence signals, which reflect hydrogen peroxide (H2O2), hypochlorite (HOCl/OCl-) and hydroxyl radicals (center dot OH) levels, showed significant positive association with PTA-low and PTA-high after adjusting for age, gender, central obesity, systemic diseases, and health-related habits (smoking, drinking, antioxidant intake). Lucigenin-dependent chemiluminescence signals, which mainly reflect superoxide anion (O-2 center dot(-)) levels, showed significant positive association with PTA-low, but not with PTA-high after adjusting for other variables. We concluded that plasma ROS levels were associated with severity of age-related hearing impairment in humans. Various ROS may differently affect auditory dysfunctions. (C) 2012 Elsevier Inc. All rights reserved.