Comparison of the effects of zinc delivered in a fortified food or a liquid supplement on the growth, morbidity, and plasma zinc concentrations of young Peruvian children
Comparison of the effects of zinc delivered in a fortified food or a liquid supplement on the growth, morbidity, and plasma zinc concentrations of young Peruvian children
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DOI：
10.1093/ajcn/85.2.538
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发表时间：
2007-02-01
影响因子：
7.1
通讯作者：
Penny, Mary E.
中科院分区：
文献类型：
--
作者：
Brown, Kenneth H.;de Romana, Daniel Lopez;Penny, Mary E.
背景：补充锌可以降低感染的发病率，促进发育迟缓儿童的生长，但关于强化食品中锌的功能反应的信息很少。目的：目的是研究锌强化对幼儿生长、感染发病率和血浆锌浓度的影响。设计：我们比较了6-8岁秘鲁儿童的身体生长、发病率和微量营养素状况，这些儿童的初始年龄长度z评分(LAZ) < -0.50，他们被随机分配接受以下治疗之一，持续6个月：1)在两餐之间分别添加30 g干重的铁强化麦片粥和单独剂量的复合维生素（MV）补充剂（对照组），2)在同样的粥和MV中添加3 mg锌（ZnSuppl组），或3)添加锌（150 mg/kg干重）的粥和不添加锌的MV （ZnFort组）。结果：儿童平均每天摄入22-26 g干粥，96%的可能MV剂量。在对社会经济地位和发病率的小基线差异进行调整后，两组之间没有观察到体重或长度增量的显著差异，即使在初始LAZ < -1.5的子集中也是如此，并且没有观察到常见疾病发生率的显著差异。对照组平均血浆锌浓度下降（-3.9 μ g/dL）， ZnSuppl组升高（4.3 μ g/dL）， ZnFort组无显著变化（-1.5 μ g/dL，组间比较P < 0.001）。结论：提供额外的锌，无论是在水补品还是强化粥中，都没有显著影响儿童的身体生长或感染发病率，可能是因为他们最初没有充分限制生长或锌缺乏，或者是因为锌的摄入或吸收水平不足。在已知对锌补充剂有反应的人群中，需要对锌强化食品的功能效果进行进一步的研究。
Background: Zinc supplementation decreases morbidity from infections and increases growth of stunted children, but there is little information on functional responses to zinc delivered in fortified foods.Objective: The aim was to examine the effects of zinc fortification on the growth, morbidity from infections, and plasma zinc concentrations of young children.Design: We compared the physical growth, morbidity, and micronutrient status of 6-8-mo-old Peruvian children with initial length-for-age z score (LAZ) < -0.50 who were randomly assigned to receive one of the following treatments daily for 6 mo: 1) 30 g dry weight of an iron-fortified cereal porridge and a separate dose of an aqueous multivitamin (MV) supplement between meals (control group), 2) the same porridge and MV with 3 mg Zn added to the supplement dose (ZnSuppl group), or 3) the porridge with added zinc (150 mg/kg dry weight) and MV without zinc (ZnFort group).Results: The children consumed a mean of 22-26 g dry porridge/d and 96% of the possible MV doses. After adjustment for small baseline differences in socioeconomic status and morbidity, no significant differences in weight or length increments were observed between the groups, even among the subset with an initial LAZ < -1.5, and no significant differences in the rates of common illnesses were observed. Mean plasma zinc concentrations decreased in the control group (-3.9 mu g/dL), increased in the ZnSuppl group (4.3 mu g/dL, and did not change significantly in the ZnFort group (-1.5 mu g/dL; P < 0.001 for group-wise comparison).Conclusions: Provision of additional zinc, either in an aqueous supplement or a fortified porridge, did not significantly affect the children's physical growth or morbidity from infections, possibly because they were not sufficiently growth-restricted or zinc-deficient initially or because the level of zinc intake or absorption was inadequate. Additional studies of the functional effect of zinc-fortified foods are needed in populations that are known to respond to zinc supplements.