LOCALIZATION OF ANDROGEN RECEPTORS AND ESTROGEN-RECEPTORS IN THE SAME CELLS OF THE SONGBIRD BRAIN
LOCALIZATION OF ANDROGEN RECEPTORS AND ESTROGEN-RECEPTORS IN THE SAME CELLS OF THE SONGBIRD BRAIN
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DOI：
10.1073/pnas.87.23.9445
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发表时间：
1990-12-01
影响因子：
11.1
通讯作者：
GAHR, M
中科院分区：
文献类型：
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作者：
GAHR, M
雌性激素和雄性激素各有其独特的作用，但它们共同作用于雄性脊椎动物（如金丝雀）的神经分化和性行为控制。这些协同作用的神经元基础是难以捉摸的，因为雌激素靶细胞和雄激素靶细胞之间的空间关系是未知的。本研究利用免疫细胞化学方法定位含雌激素受体（ER）的细胞，利用放射自显影技术定位含雄激素受体（AR）的细胞。在组织特异性频率中发现了三种细胞类型，即同时含有ER和AR的细胞类型。中脑核丘间核同时表达ER和AR的细胞数量最多，而ER和AR仅在前脑腹侧高纹状体核的分离细胞群中表达。雄激素和雌激素对神经行为控制的协同作用可能来自同时含有ER和AR的细胞（细胞内）和不同细胞中含有ER和AR的神经回路（细胞间）。
Estrogens and androgens each have unique effects but act together for the neural differentiation and control of sexual behaviors in male vertebrates, such as the canary. The neuronal basis for these synergistic effects is elusive because the spatial relation between estrogen target cells and androgen target cells is unknown. This study localized estrogen receptor (ER)-containing cells by using immunocytochemistry and androgen receptor (AR)-containing cells by using autoradiography in the same sections of the male canary brain. Three cell types, those containing both ER and AR, were found in tissue-specific frequencies. The midbrain nucleus intercollicularis exhibited the highest number of cells expressing both ER and AR, whereas ER and AR are expressed only in disjunctive cell populations in the forebrain nucleus hyperstriatalis ventrale, pars caudale. Synergistic effects of androgens and estrogens for the neural behavioral control could result from cells containing both ER and AR (intracellular) and from neural circuits containing ER and AR in different cells (intercellular).