MEDIATION BY G-PROTEINS OF SIGNALS THAT CAUSE COLLAPSE OF GROWTH CONES
MEDIATION BY G-PROTEINS OF SIGNALS THAT CAUSE COLLAPSE OF GROWTH CONES
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DOI：
10.1126/science.8418498
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发表时间：
1993-01-01
期刊：
影响因子：
56.9
通讯作者：
FISHMAN, MC
中科院分区：
文献类型：
--
作者：
IGARASHI, M;STRITTMATTER, SM;FISHMAN, MC
在发育过程中，神经生长锥的运动在与特定目标接触时停止。信号机制尚不清楚。在培养中，生长锥塌陷可由溶解的胚胎脑膜、中枢神经系统髓鞘（从髓鞘分离的35千道尔顿蛋白质）和mastoparan引起。百日咳毒素可阻断上述每一种引起的虚脱。因此，生长锥的塌陷是由G蛋白偶联受体介导的，G蛋白偶联受体可以被与细胞表面相关的蛋白质以及可溶性配体激活。
During development, motion of nerve growth cones ceases on contact with particular targets. The signaling mechanism is unknown. In culture, growth cone collapse can be caused by solubilized embryonic brain membranes, central nervous system myelin, a 35-kilodalton protein isolated from myelin, and mastoparan. Collapse induced by each of these is blocked by pertussis toxin. Thus, collapse of growth cones is mediated by G protein-coupled receptors, which may be activated by proteins associated with the cell surface as well as by soluble ligands.