Rapid oligosaccharide synthesis using a fluorous protective group
Rapid oligosaccharide synthesis using a fluorous protective group
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DOI：
10.1021/jo049425k
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发表时间：
2004-08-06
影响因子：
3.6
通讯作者：
Inazu, T
中科院分区：
文献类型：
--
作者：
Miura, T;Goto, K;Inazu, T
Bfp-OH是一种新型的氟保护剂，制备简单。Bfp基团容易地被引入到碳水化合物中，以高产率去除，并且在切割后可再循环。Bfp基团的使用使得可以通过最小的柱色谱纯化来合成五糖。每种合成中间体仅通过简单的氟-有机溶剂萃取就能够容易地纯化，并通过TLC、NMR和MS进行监测。
The Bfp-OH, a novel fluorous protecting reagent, was able to be easily prepared. The Bfp group was readily introduced to a carbohydrate, removed in high yield, and recyclable after cleavage. The use of the Bfp group made it possible to synthesize a pentasaccharide by minimal column chromatography purification. Each synthetic intermediate was able to be easily purified only by simple fluorous-organic solvent extraction and monitored by TLC, NMR, and MS.