ALTERED CELLULAR IMMUNE FUNCTIONS IN PATIENTS WITH DOWNS-SYNDROME
ALTERED CELLULAR IMMUNE FUNCTIONS IN PATIENTS WITH DOWNS-SYNDROME
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DOI：
10.1001/archpedi.1981.02130270043015
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发表时间：
1981-01-01
影响因子：
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通讯作者：
GROSSMAN, HJ
中科院分区：
文献类型：
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作者：
SPINA, CA;SMITH, D;GROSSMAN, HJ
对42例唐氏综合征（DS）患者的细胞相关免疫活性进行了评价，并与住院患者对照组和正常对照组进行了比较。DS患者的B淋巴细胞占淋巴细胞总数的百分比和绝对数量均显著减少。T淋巴细胞对植物血凝素有丝分裂原的增殖反应也显著降低。淋巴细胞群体的这种改变的反应在辅助单核细胞的存在和不存在下都是明显的。在DS患者和对照患者中均观察到Fc受体（FcR）细胞活性增加（通过抗体依赖性细胞毒性测定）。这可能是由于常见的环境因素，如接触传染性病原体。未发现白色血细胞计数、淋巴细胞和单核细胞百分比、T细胞和FcR细胞百分比或自然杀伤细胞活性发生变化。
Cell-associated immunocompetence was evaluated in 42 patients with Down''s syndrome (DS) and compared with that of institutionalized patient control and normal control groups. B lymphocytes, as both percent of total lymphoid cells and absolute number, were markedly reduced in patients with DS. T lymphocyte proliferative response to phytohemagglutinin mitogen also was significantly decreased. This altered response of the lymphocyte population was evident in both the presence and absence of accessory helper monocytes. Increased Fc receptor (FcR) cell activity, as measured by antibody-dependent cellular cytotoxicity was seen in both the patients with DS and the control patients. This probably resulted from common environmental factors such as exposure to infectious agents. No change was found in the white blood cell counts, percentages of lymphocytes and monocytes, percentages of T cells and FcR cells, or in the natural killer cell activity.