Insulin-like growth factor-binding proteins and bone metabolism
Insulin-like growth factor-binding proteins and bone metabolism
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DOI：
10.1152/ajpendo.00648.2007
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发表时间：
2008-01-01
影响因子：
5.1
通讯作者：
Conover, Cheryl A.
中科院分区：
文献类型：
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作者：
Conover, Cheryl A.
胰岛素样生长因子结合蛋白(IGFBPs)是重要的骨代谢调节因子。然而，它们的确切作用尚不完全清楚，因为IGFBPs对IGF的作用既有促进作用，也有抑制作用，这取决于上下文和翻译后修饰，以及IGF非依赖的影响。本文综述了细胞培养、啮齿动物模型和临床研究中有关局部IGFBP-2、IGFBP-4和IGFBP-5在骨骼中作用的最新发现。
Insulin-like growth factor-binding proteins (IGFBPs) are important regulators of bone metabolism. However, their precise roles are not fully understood, since IGFBPs can have both enhancing and inhibiting effects on IGF action, depending on context and posttranslational modifications, as well as IGF-independent effects. This review focuses on recent findings from cell culture, rodent models, and clinical studies concerning local IGFBP-2, IGFBP-4, and IGFBP-5 action in bone.