Quantitative radionuclide angiography in assessment of hemodynamic changes during upright exercise: observations in normal subjects, patient with coronary artery disease and patients with aortic regurgitation.
Quantitative radionuclide angiography in assessment of hemodynamic changes during upright exercise: observations in normal subjects, patient with coronary artery disease and patients with aortic regurgitation.
复制标题
定量放射性核素血管造影评估直立运动期间血流动力学变化：在正常受试者、冠状动脉疾病患者和主动脉瓣反流患者中的观察。
DOI：
10.1016/0002-9149(81)90602-0
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Bernard L. Segal
中科院分区：
文献类型：
--
作者：
A. Iskandrian;A. Hakki;S. Kane;Bernard L. Segal
定量放射性核素血管造影（采用首次通过技术和计算机化多晶相机）用于评估三个受试者组在症状限制的直立运动期间的血流动力学变化。 12名正常受试者运动时心率、每搏输出量、左心室射血分数和心输出量均显着增加；舒张末期和收缩末期容积的变化并不显着。在 24 名冠状动脉疾病患者中，运动期间心率和心输出量显着增加，但舒张末期、收缩末期、每搏输出量和射血分数变化不显着。这些患者舒张期容积的变化取决于冠状动脉疾病的程度、普萘洛尔治疗、运动终点和侧支血管的存在。此外，与没有心肌梗塞的患者相比，既往有心肌梗塞的患者在运动时射血分数较低，舒张末期和收缩末期容量较高。 12例中重度慢性主动脉瓣关闭不全患者，运动时出现舒张末期容积下降。这种反应与正常受试者或冠状动脉疾病患者的反应明显不同。所有三组在运动过程中肺传输时间均显着减少。结论是，正常受试者在直立运动过程中心输出量的变化与每搏输出量的增加和心动过速有关，而在冠状动脉疾病患者中，它们主要与心动过速有关。运动期间左心室扩张发生在一些正常受试者和患有冠状动脉疾病的患者中，但这并不是一致的发现。然而，主动脉瓣关闭不全的患者左心室舒张末期容积减少很常见。这种减少可以通过舒张期充盈期缩短或全身血管阻力减少或两者兼而有之引起的每次心跳返流量减少来解释。
Quantitative radionuclide angiography (with the first pass technique and a computerized multicrystal camera) was used to evaluate hemodynamic changes in three subject groups during symptom-limited upright exercise. The 12 normal subjects had significant increases in heart rate, stroke volume, left ventricular ejection fraction and cardiac output during exercise; changes in end-diastolic and end-systolic volumes were not significant. In the 24 patients with coronary artery disease there were significant increases in heart rate and cardiac output during exercise, but insignificant changes in end-diastolic, end-systolic and stroke volumes and ejection fraction. The change in diastolic volume in these patients was determined by the extent of coronary artery disease, propranolol therapy, end point of exercise and presence of collateral vessels. Furthermore, patients with previous myocardial infarction had a lower ejection fraction and higher end-diastolic and end-systolic volumes during exercise than those without myocardial infarction. In the 12 patients with chronic aortic regurgitation of moderate to severe degree, there was a decrease in the end-diastolic volume during exercise. This response was distinctiy different from that of the normal subjects or the patients with coronary artery disease. All three groups had a significant decrease in pulmonary transit time during exercise.It is concluded that changes in cardiac output in normal subjects during upright exercise are related to augmentation of stroke volume and tachycardia, whereas in patients with coronary artery disease they are related mainly to tachycardia. Left ventricular dilatation during exercise occurred in some normal subjects and in patients with coronary artery disease but was not a consistent finding. However, a decrease in left ventricular end-diastolic volume is common in patients with aortic regurgitation. Such a decrease may be explained by a reduction in the regurgitant volume per beat caused by shortening of the diastolic filling period or a decrease in systemic vascular resistance, or both.
定量放射性核素血管造影。
DOI：
10.1002/ccd.1810060307
发表时间：
1980
期刊：
Catheterization and cardiovascular diagnosis
影响因子：
--
作者：
Scholz,PM;Rerych,SK;Moran,JF;Newman,GE;Douglas,JM;SabistonJr,DC;Jones,RH
通讯作者：
Jones,RH