Assignment of the human and mouse prion protein genes to homologous chromosomes.
Assignment of the human and mouse prion protein genes to homologous chromosomes.
复制标题
将人和小鼠朊病毒蛋白基因分配给同源染色体。
DOI：
10.1073/pnas.83.19.7358
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发表时间：
1986
影响因子：
11.1
通讯作者：
Mohandas,T
中科院分区：
文献类型：
--
作者：
Sparkes,RS;Simon,M;Cohn,VH;Fournier,RE;Lem,J;Klisak,I;Heinzmann,C;Blatt,C;Lucero,M;Mohandas,T
痒病朊病毒的纯化制剂含有一个主要的大分子，称为朊蛋白（PrP）。编码PrP的基因在正常动物和人类中发现，但不在传染性颗粒中发现。利用体细胞杂交技术将PrP基因分别植入人的20号染色体和小鼠的2号染色体。原位杂交研究将人类PrP基因定位到20p12条带----pter。我们的研究结果将导致与PrP基因同源的基因位点的研究，它可能在朊病毒疾病或其他退行性神经系统疾病的发病机制中发挥作用。
Purified preparations of scrapie prions contain one major macromolecule, designated prion protein (PrP). Genes encoding PrP are found in normal animals and humans but not within the infectious particles. The PrP gene was assigned to human chromosome 20 and the corresponding mouse chromosome 2 using somatic cell hybrids. In situ hybridization studies mapped the human PrP gene to band 20p12----pter. Our results should lead to studies of genetic loci syntenic with the PrP gene, which may play a role in the pathogenesis of prion diseases or other degenerative neurologic disorders.