A Retrospective Study Predicting Psychological Vulnerability in Adult Daughters of Breast Cancer Patients
A Retrospective Study Predicting Psychological Vulnerability in Adult Daughters of Breast Cancer Patients
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DOI：
10.1037/a0029638
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发表时间：
2012-09-01
影响因子：
1.3
通讯作者：
Owen, Jason E.
中科院分区：
文献类型：
--
作者：
Wellisch, David K.;Ormseth, Sarah R.;Owen, Jason E.
本研究试图在两组乳腺癌患者的女儿中确定易感因素。一组由母亲患乳腺癌后幸存下来的女儿组成，另一组由母亲死于乳腺癌的女儿组成。结果显示主效应显著。更多的照顾与更高水平的癌症相关的悲伤有关。母亲死于乳腺癌预示着癌症相关抑郁的水平更高。此外，女儿的抑郁症诊断史与当前的抑郁症状有关。还出现了几个重要的相互作用。母亲的生存状况和女儿参与母亲乳腺癌的程度对女儿目前的抑郁症状有显著影响。与母亲患乳腺癌关系最密切的女儿，其当前抑郁症状的程度最高。在母亲确诊时年龄小于12岁的女儿比母亲确诊时年龄在12到19岁的女儿报告的当前状态焦虑明显更高。母亲死于乳腺癌且过去曾被诊断为抑郁症的女儿，其患癌症相关抑郁症的程度明显高于没有被诊断为抑郁症的女儿。我们得出的结论是，在报告照顾参与程度极低的女儿中，产妇死亡反映出最容易出现当前抑郁症状。我们还得出结论，具有潜在抑郁遗传易感性的女儿对创伤性生活事件（如母亲疾病和死亡）最敏感。
This study was an attempt to identify vulnerability factors in two cohorts of daughters of breast cancer patients. One cohort consisted of daughters whose mothers survived breast cancer and the other consisted of daughters whose mothers died from breast cancer. The results revealed significant main effects. Greater caretaking involvement was associated with higher levels of cancer-related grief. Maternal loss to breast cancer predicted higher levels of cancer-related depression. Also, a history of a depression diagnosis in the daughters was associated with current depressive symptoms. Several significant interactions also emerged. Survival status of the mother and level of daughters' involvement in mother's breast cancer was shown to significantly affect the daughters' current depressive symptoms. Daughters who reported the lowest level of involvement with their mother's breast cancer reported the highest level of current depressive symptoms. Daughters who were less than 12 years of age at the time of their mother's diagnosis reported significantly higher current state anxiety than daughters who were 12 to 19 at the time of their mother's diagnosis. Daughters whose mothers died from breast cancer, who also had a past diagnosis of depression, reported significantly higher levels of cancer-related depression than daughters without a past diagnosis of depression. We concluded that maternal death among daughters who reported very low caretaking involvement reflects the most significant vulnerability to show current depressive symptoms. We also concluded that daughters possessing potential genetic vulnerability to depression are the most sensitized to traumatic life events such as maternal illness and death.