Premedication with cyclooxygenase-2 inhibitor meloxicam reduced postoperative pain in patients after oral surgery
Premedication with cyclooxygenase-2 inhibitor meloxicam reduced postoperative pain in patients after oral surgery
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DOI：
10.1016/j.ijom.2006.01.026
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发表时间：
2006-07-01
影响因子：
2.4
通讯作者：
Kaneko, A.
中科院分区：
文献类型：
--
作者：
Aoki, T.;Yamaguchi, H.;Kaneko, A.
在一项随机对照试验中评估了选择性环氧合酶-2（考克斯-2）抑制剂美洛昔康治疗口腔手术后疼痛的疗效。将行单侧下颌第三磨牙拔除术的患者随机分为A、B、C 3组。A组术前口服美洛昔康10 mg，B组口服安吡昔康27 mg，C组口服安慰剂，均在2%利多卡因局麻下于30 min内完成手术。为了缓解术后疼痛，允许患者口服洛索洛芬（60 mg/片）。于术后第1、7、14天（POD）在门诊采用视觉模拟评分法（VAS）评价术后疼痛程度，并记录洛索洛芬片的消耗量，3组间比较，P < 0.05，具有统计学意义。术后I POD VAS评分A组明显低于C组。A组手术当天和I-POD时洛索洛芬用量明显低于C组（P < 0.01）。A、B组镇痛药总用量明显低于C组（P < 0.02）。与对照组相比，术前使用考克斯-2抑制剂美洛昔康10 mg可减轻口腔手术的术后疼痛。
The efficacy of the selective cyclooxygenase-2 (COX-2) inhibitor meloxicam for treatment of postoperative oral surgical pain was assessed in a randomized controlled trial. Patients undergoing unilateral mandibular 3rd molar extraction surgery were allocated to 3 groups, A, B and C. After oral premedication of meloxicam 10 mg in group A, ampiroxicam 27 mg in group B and placebo in group C, surgery was completed within 30 min under local anaesthesia using 2% lidocaine. For postoperative pain relief the patients were allowed to take oral loxoprofen (60 mg per tablet). Postoperative pain was evaluated at the clinic on the 1st, 7th and 14th postoperative day (POD) using a visual analogue scale (VAS), as was the number of loxoprofen tablets consumed, and the results were compared among the 3 groups with statistical significance of P < 0.05. VAS scores on I POD were significantly lower in group A than in group C. Loxoprofen consumption on the day of surgery and I POD was significantly lower in group A than in group C (P < 0.01). Total analgesic consumption was significantly lower in groups A and B than in group C (P < 0.02). The COX-2 inhibitor, meloxicam 10 mg used for premedication reduced postoperative pain compared with control in oral surgery.