Defective protective capacity of W/Wv mice against Strongyloides vatti infection and its reconstitution with bone marrow cells
Defective protective capacity of W/Wv mice against Strongyloides vatti infection and its reconstitution with bone marrow cells
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W/Wv小鼠对华氏类圆线虫感染的保护能力缺陷及其骨髓细胞重建
DOI：
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发表时间：
1985
期刊：
影响因子：
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通讯作者：
M. Kotani
中科院分区：
文献类型：
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作者：
Y. Nawa;M. Kiyota;M. Korenaga;M. Kotani
摘要研究了先天性贫血和肥大细胞缺陷的W/WV小鼠对Ratti类圆线虫感染的易感性。在初次感染后，W/WV小鼠表现出比正常产仔更多和更持久的高峰幼虫数量。W/WV小鼠的驱虫速度也慢于+/+小鼠。此外，易感性的差异早在感染后24小时就表现出来，这表明W/WV小鼠不仅肠道的保护机制存在缺陷，结缔组织的保护机制也存在缺陷。用+/+小鼠的骨髓或脾细胞重建W/WV小鼠的保护性反应是有效的，而胸腺细胞或肠系膜淋巴结则不起作用。W/WV小鼠在骨髓重建和感染后，结缔组织和粘膜肥大细胞均得到修复。由于这种重组活性的表达需要较长的潜伏期，因此骨髓细胞似乎含有效应器和/或调节细胞的前体细胞。
Summary The susceptibility of congenitally anemic, and mast cell deficient W/Wv mice to infection with Strongyloides ratti was examined. After a primary infection, W/Wv mice showed greater and more persistent peak larval counts than did normal littermates. Worm expulsion was also slower in W/Wv mice than in +/+ mice. Furthermore, difference in susceptibility was expressed as early as 24 h after infection, suggesting not only that protective mechanisms of the gut but also of the connective tissue were defective in W/Wv mice. Reconstitution with bone marrow or spleen cells from +/+ mice was effective in restoring the protective response in W/Wv mice, whereas thymocytes or mesenteric lymph nodes had no effect. Both connective tissue and mucosal mast cells were repaired in W/Wv mice after marrow reconstitution and infection. Since relatively long incubation period was required for the expression of such reconstituting activities, bone marrow cells seem to contain precursor cells of the effector and/or regulator cells.
鼠类圆线虫：将大鼠的保护性免疫分解为全身和肠道成分。
影响因子：
2.1
作者：
Bell,RG;Adams,LS;Gerb,J
通讯作者：
Gerb,J