Balancing Inflammation: The Link between Th17 and Regulatory T Cells.
Balancing Inflammation: The Link between Th17 and Regulatory T Cells.
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DOI：
10.1155/2016/6309219
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发表时间：
2016
影响因子：
4.6
通讯作者：
Ford ML
中科院分区：
文献类型：
--
作者：
Diller ML;Kudchadkar RR;Delman KA;Lawson DH;Ford ML
小鼠和人的CD 4 + T细胞区室由多个不同的亚群组成，每个亚群具有独特的表型和功能特征。产生IL-17的CD 4 + T细胞（Th 17细胞）代表CD 4 + T细胞谱系的不同亚群。最近的证据表明，Th 17细胞执行类似于细胞毒性CD 8 + T细胞的效应子功能，并在清除细胞外病原体和真菌中发挥重要作用。Th 17细胞的分化和功能与调节性T细胞（Treg）的发育和功能密切相关。这两种细胞群之间的平衡对于免疫稳态是必不可少的，并且这种平衡的失调已经涉及多种炎性病症，包括自身免疫、同种异体移植物排斥和肿瘤发生。新出现的证据报告了Th 17和调节性T细胞区室之间的大量可塑性，这些细胞相互交流和影响的机制才刚刚开始被理解。在这篇综述中，我们重点介绍了最近的研究结果，详细说明了驱动Th 17和TREG可塑性的机制，并讨论了它们之间独特关系的生物学后果。
CD4+ T cell compartments in mouse and man are composed of multiple distinct subsets each possessing unique phenotypic and functional characteristics. IL-17-producing CD4+ T cells (Th17 cells) represent a distinct subset of the CD4+ T cell lineage. Recent evidence suggests that Th17 cells carry out effector functions similar to cytotoxic CD8+ T cells and play an important role in the clearance of extracellular pathogens and fungi. Th17 cell differentiation and function are closely related to the development and function of regulatory T cells (TREG). The balance between these two cell populations is essential for immune homeostasis and dysregulation of this balance has been implicated in a variety of inflammatory conditions including autoimmunity, allograft rejection, and tumorigenesis. Emerging evidence reports a significant amount of plasticity between the Th17 and regulatory T cell compartments, and the mechanisms by which these cells communicate and influence each other are just beginning to be understood. In this review, we highlight recent findings detailing the mechanisms driving Th17 and TREG plasticity and discuss the biologic consequences of their unique relationship.