Vascular measures of atherosclerosis in detrusor overactivity and controls
Vascular measures of atherosclerosis in detrusor overactivity and controls
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DOI：
10.1002/nau.23784
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发表时间：
2018-11-01
影响因子：
2
通讯作者：
Moore, Kate H.
中科院分区：
文献类型：
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作者：
Ladanchuk, Todd;Kwak, Seojung;Moore, Kate H.
目的方法逼尿肌过度活动（DO）的发病机制目前尚不清楚，但动物实验表明动脉粥样硬化和膀胱血流量减少可能是其发病机制之一。因此，本研究的目的是评估动脉粥样硬化的迹象，在一个大的队列的妇女逼尿肌过度活动，使用两个精确的测量动脉粥样硬化血管损伤，踝臂指数（ABI），和Brachialankle脉搏波速度（baPWV）。采用自动血压计测量ABI和baPWV，以评估DO患者和对照组的动脉粥样硬化程度。ABI和baPWV和重要的混杂变量之间的关联进行了评估，通过线性回归model.ResultsConclusionsNinety-eight妇女DO，和98个控制没有任何症状的DO进行了研究。多变量分析显示，有无逼尿肌过度活动（以及年龄、舒张压和体重指数等独立因素）可显著预测左侧baPWV增加约96 cm/s单位的流速（95%CI 20.65-172.05，P=0.01）。在线性回归模型中，当控制年龄、BMI和舒张压（DBP）时，DO的存在是PWV增加的强预测因子，从而支持动脉粥样硬化可能导致DO病因的假设。
AimMethodsThe mechanisms leading to the development of detrusor overactivity (DO) are still relatively poorly understood, however, animal studies suggest that atherosclerosis and reduced blood flow to the bladder may be one etiological pathway. Thus, the aim of this study was to evaluate signs of atherosclerosis in a large cohort of women with detrusor overactivity, using two precise measures of atherosclerotic vascular impairment, Ankle Brachial Index (ABI), and Brachialankle Pulse Wave Velocity (baPWV).A prospective cohort study measuring ABI and baPWV of women with DO and controls was conducted. The ABI and baPWV were measured using an automated oscillometric blood pressure machine, to evaluate the degree of atherosclerosis in patients with DO and controls. Associations between ABI and baPWV and important confounding variables were assessed by a linear regression model.ResultsConclusionsNinety-eight women with DO, and 98 controls without any symptoms of DO were studied. Multivariate analysis showed an increase in left baPWV of approximately 96cm/s units of velocity (95%CI 20.65-172.05, P=0.01) is predicted significantly by the presence or absence of detrusor overactivity (as well by independent factors of age, diastolic blood pressure and body mass index). A similar effect was seen for right baPWV.On linear regression modeling, the presence of DO was a strong predictor for an increased PWV when controlling for age, BMI and diastolic blood pressure (DBP), thus supporting the hypothesis that atherosclerosis may contribute to the etiology of DO.