COMMUNITY-BASED PREVALENCE PROFILE OF ARBOVIRAL, RICKETTSIAL, AND HANTAAN-LIKE VIRAL ANTIBODY IN THE NILE RIVER DELTA OF EGYPT
COMMUNITY-BASED PREVALENCE PROFILE OF ARBOVIRAL, RICKETTSIAL, AND HANTAAN-LIKE VIRAL ANTIBODY IN THE NILE RIVER DELTA OF EGYPT
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DOI：
10.4269/ajtmh.1993.48.776
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发表时间：
1993-06-01
影响因子：
3.3
通讯作者：
KILPATRICK, M
中科院分区：
文献类型：
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作者：
CORWIN, A;HABIB, M;KILPATRICK, M
为了确定目前虫媒病毒、立克次体和汉坦样病毒抗体的流行情况，在埃及尼罗河流域进行了一项调查，该流域是1977-1978年裂谷热暴发的主要疫源地之一。从代表190个研究家庭的915人中获得血液样本。酶免疫检测结果显示，西西里白蛉热（SFS）IgG抗体总流行率为4%，那不勒斯白蛉热（SFN）为2%，裂谷热（RVF）为15%，西尼罗河病毒为20%，汉滩病毒为4%。在同一研究对象中，贝氏柯克斯体抗体阳性率为32%，伤寒立克次体抗体阳性率为58%，立克次体抗体阳性率为32%。科诺里。病原体特异性抗体的检出率随年龄增长而增高。特别值得注意的是，在裂谷热爆发高峰期之后出生的儿童中，裂谷热感染率很低。在7岁以下的人群中没有发现可检测到的抗体，7-12岁的人群中只有3%。相比之下，在13-19岁的研究人群中，发现26%的人（在暴发时是幼儿和婴儿）有裂谷热抗体，这表明在记录在案的1977-1978年暴发之后，与传播有关的强度大大降低。几何平均滴度（GMT）从贝氏锥虫的139到裂谷热的1 305不等，除20-49岁年龄组裂谷热滴度较高外，不同年龄组之间没有显著差异。当在标本中检测到一种以上静脉病毒抗体时，也注意到GMT呈显著上升趋势。在SFS、SFN和RVF中观察到这一点，即，单纯裂谷热1，172例，裂谷热和SFN 1，334例，裂谷热合并SFS 1，828例，裂谷热合并SFN和SFS 2，111例（P < 0.05）。这些数字证实了当发现一种静脉病毒的抗体与其他病毒相关时发现的加强现象。这些发现表明立克次体抗体的普遍存在，并保证与获得性感染相关的疾病发病率的进一步研究。此外，感染病例在家庭中的家族聚集性仅在贝氏锥虫、R. typhi和R. conorii，并且与性别无关。
To determine the current prevalence of antibody to arboviruses, rickettsiae, and hantaan-like viruses, a survey was carried out in the Nile River Valley of Egypt, one of the principal foci of the 1977-1978 Rift Valley fever (RVF) outbreak. Blood specimens were obtained from 915 persons representing 190 study households. Enzyme immunoassay testing showed that the overall prevalence of IgG antibody was 4% to sand fly fever Sicilian (SFS), 2% to sandfly fever Naples (SFN), 15% to RVF, 20% to West Nile, and 4% to Hantaan (HTN) viruses. Antibody was demonstrated among 32% of the same study subjects to Coxiella burnetii, 58% to Rickettsia typhi, and 32% to R. conorii. The prevalence of agent-specific antibody tended to increase with age. Particularly notable was the low prevalence of RVF infection in children born after the height of the RVF outbreak. No detectable antibodies were found in the population less than seven years of age and in only 3% of those 7-12 years old. In contrast, 26% of the study population 13-19 years old, who were young children and infants at the time of the outbreak, were found to have RVF antibodies, suggesting that the level of intensity associated with transmission decreased considerably following the documented 1977-1978 outbreak. Geometric mean titers (GMT) ranged from 139 for C burnetii to 1,305 for RVF, and did not vary significantly by age, except for high titers for RVF in the 20-49-year-old age group. A significant upward trend in GMT was also noted when antibody was detected in the specimen for more than one phlebovirus. This was observed for SFS, SFN, and RVF, i.e., 1,172 for RVF only, 1,334 for RVF and SFN, 1,828 for RVF with SFS, and 2,1 11 for RVF with SFN and SFS (P < 0.05). These figures attest to the boosting phenomenon found when antibody for one phlebovirus is found in association with others. These findings show prevalences of rickettsial antibodies and warrant further study of disease incidence associated with acquired infection. Additionally, familial clustering of infected cases in households was evident only for C burnetii, R. typhi, and R. conorii, and was independent of sex.